A room-temperature metal-free method for generating highly unstable methyl radical was realized from the combination of PhI(OAc) 2 and 2-nitropropane, which provides an efficient approach to methylated phenanthridines and isoquinolines. The strategy was also extended to the generation of other alkyl radicals and a concise synthesis of Roxadustat.
A radical cascade decarboxylation/cyclization of 2-isocyanobiphenyls with aliphatic carboxylic acids as well as aromatic carboxylic acids under the transition metal-free conditions was reported. This process, which included formation of two new C-C bonds and cleavage of C-COOH bonds, afforded a novel and environmentally friendly approach to producing 6-alkyl/aryl phenanthridines with moderate to good yields.
Alkyl or alkenyl N,N-dimethylchalcogenocarbamates were easily prepared by a stepwise treatment of bis(N,N-dimethylcarbamoyl) dichalcogenides with NaH or NaBH4, followed by various alkylating agents or acetylenes bearing electron-withdrawing substituents. The one-step conversion of alkyl or alkenyl N,N-dimethylselenocarbamates or N,N-dimethyltellurocarbamates into the corresponding symmetrical dialkyl or dialkenyl dichalcogenides was also achieved efficiently by treating with SnCl4.
A Schiff base fluorescent probe, naphthalic anhydride -(2-pyridine) hydrazone (NAH), has been synthesized and developed for highly selective and sensitive monitoring of Fe3+ ions in aqueous solution and living cells....
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