Nitric oxide (NO) is a small molecule implicated in multiple signal transduction pathways thus contributing to the regulation of many cellular functions. The identification of NO synthase (NOS) isoforms and the subsequent characterization of the mechanisms of cell activation of the enzymes permitted the partial understanding of both the physiological and pathological processes. NO bioavailability plays an important role in the pathophysiology of cardiovascular disease and its reduction in endothelial cells is strictly associated to endothelial dysfunction which, in turn, correlates with cardiovascular mortality. Indeed, endothelial NO synthase (eNOS) has a key role in limiting cardiac dysfunction and remodeling in heart diseases, in part by decreasing myocyte hypertrophy. Conversely, exercise training is recommended to prevent and treat cardiovascular diseases-associated disorders at least by enhanced NO synthase activity and expression, and increased production of antioxidants, which prevents premature breakdown of NO. Exercise training may cause an improvement in endothelial function for both experimental animals and humans; Studies in both healthy subjects and patients with impaired NO-related vasorelaxation remarked exercise training ability to improve vascular structure and function and endothelial homeostasis. This chapter will briefly consider the importance of NO signaling in the maintenance of cardiovascular physiology, and discuss recent insights into the effect of exercise training on the signaling pathways that modulate NO synthesis and degradation in health and cardiovascular disease. In addition, we will highlight the molecular mechanisms via which microRNAs (miRs) target NO signaling in the cardiovascular system, and NO as a candidate molecule for development of new therapies.
Manystudies have beenconducted onfastingduring the monthof Ramadan;however, their resultswerevastly inconsistent.Itis importanttonote thatnone of these studiescontrolledor evenmonitoredphysical activityandfoodintake.PurposeThisstudy willdetermineifintermittentfastingwillaffectbody composition, blood lipid profile,glucose, blood proteins and hormones.MethodsEight healthyathletemales participatedinthisstudy.Weight,height andbody compositionofallsubjectswererecordedatbaselineoneday before Ramadan(D1),after ten daysof fastingRamadan(D10) andtwenty‐eightdaysof fastingRamadan (D28). All data was analyzed using 1x3 repeatedmeasuresANOVA(p<.05).ResultsThere wassignificantdecreasein bodymassandLeanbody masscomparingD28withD1andD10.Vigorousactivityand ModerateactivityweresignificantlydecreaseatD10andD28ofRamadan. Thepercentagewhichrecommendeddietary allowancesof caloriesfromproteinshowedsignificantdecreaseatD10andD28comparetoD1.Inaddition,the percentage of calories fromcarbohydrate showedsignificant increaseatD10andD28comparetoD1.FastedGlucoselevelsweresignificantly increasedat D10compareto D1. Glucagondecreasesignificantly at D10, but not at D28.Inaddition,Albumin levelsweresignificantlyloweratD10andD28compareto D1;however,all measurements were stillwithinnormal/healthrange.ConclusionResultsshowthelevelofphysicalactivity andfoodintakeare majorcontributingfactorsonthereductioninbodyweight.Overall,thesefindingsindicatenohealthriskforfastingthe month of Ramadan.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.