The ]Sodium Carboxymethyl Cellulose-grafting-Poly(Acryl Amide-Acrylic Acid) [ hydrogel was synthesized through free radical polymerization method of CMC, AAm, and AAc. Potassium persulfate(KPS) and N, N methylene bis-acrylamide (MBA) were used as initiator and crosslinking agent, respectively. FTIR, XRD, FESEM, and TGA were used to characterize the synthesized hydrogel. The hydrogel was used to remove metformin hydrochloride drug from aqueous solutions. The analysis clarifies the effect of several parameters on the quantity of adsorbate, including pH at a range of (1.2-12), the temperature at a range of (15, 20, 25 and 30°C), equilibrium time (1-240 min), and adsorbate weight at a range of (0.001-0.1 g). It is discovered that as temperature increases and pH decreases, the quantity of adsorbate present decreases. Equilibrium time 120 min. The adsorption isotherm seems to indicate that the adsorption mechanism followed Freundlich and Temkin models. Thermodynamic functions were measured, and it was discovered that the adsorption mechanism is exothermic and spontaneous.
In this study, based on the free radical polymerization, a high-efficiency sodium carboxymethyl cellulose-grafted-Poly (acryl acid-acrylic amide) (SCC-g-Poly (AAc-AAm) hydrogel was prepared using initiators for the generation of free radicals (KPs) and a cross-linking agent, N,N’-Methylene-bis-acrylamide (MBA) as well as loading silver nanoparticles onto SCC-g-poly (AAc-AAm) hydrogel cross-linked by silver nitrate was added at the concentration (1000 mg/L) for about one day to load silver ions on the surface. utilized this AgNP/SCC-g-poly (AAc-AAm) hydrogel to drug release of metformin hydrochloride (MH) was studied at different acid mediums (pH = 7.4 and 1.2) and temperatures of 37℃. This study then studied the ability of the surface to release silver controlled. Field emission scanning electron microscopy (FESEM), Fourier-transform infrared (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), atomic force microscopy (AFM) as well as Brunauer–Emmett–Teller (BET), were among the techniques used to examine the prepared surface’s properties. The highest reported drug release rates occurred at (pH = 7.4) when the rate of drug release was 97.19% after 500 minutes. This is caused by the hydrogel containing COOH, C=O, and OH groups that ionize in the neutral medium (pH = 7.4), forming negative ions, which electrostatically repel each other with the unshared electron pair of the NH group. On the contrary to in an acidic medium (pH = 1.2), the hydrophilic groups included in the hydrogel composition are saturated, making them bond with hydrogen bonds with each other and the percentage of swelling of hydrogel is very small. Two different bacteria species (Gram-negative and Gram-positive bacteria) were used to study the AgNP/SCC-g-poly (AAc-AAm) hydrogel and the ability of the surface to inhibit the two types of bacteria.
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