Some new amidated fentanyl (=N‐[1‐(2‐phenylethyl)piperidin‐4‐yl]‐N‐phenylpropanamide) analogs with a 4‐(N‐phenylamido)piperidine scaffold and additional amide bonds have been designed and synthesized through Ugi four‐component reaction (Ugi‐4CR). Good‐to‐high yields, diversity‐oriented synthesis, and possible applications in drug discovery are advantages of this approach.
In the title compound, C19H23IN2O2, the cyclohexane ring adopts a chair conformation, and the mean plane of the propiolamide unit is approximately perpendicular to the benzene ring [dihedral angle = 88.12 (13)°]. Weak intramolecular C—H⋯O hydrogen bonding is observed between the carbonyl group and the benzene ring. In the crystal, classical N—H⋯O hydrogen bonds and weak C—H⋯O interactions are present.
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