The present study aims to consider the effects of age on liver enzyme levels of obese men following 15 weeks of moderate-intensity interval training (MIIT). Ten obese middle-aged persons (aged 55.2 ± 4.31 years; height 171.4 ± 3.59 cm; weight 95.7 ± 14.61 kg; and body mass index [BMI] 32.53 ± 4.59 kg/m2) and 10 obese young adults (age 22.7 ± 1.25 years; height 177.4 ± 3.94 cm; weight 100.7 ± 8.04 kg; and BMI 32 ± 2.39 kg/m2) were enrolled in this study. Interval training was followed by 65 to 75% of VO2max, 1 set, 2 minutes and seven repetitions, 1 minute rest–relief interval with 50% of VO2max. Blood sampling was carried out in order to measure aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). All analyses were conducted by Statistical Package for the Social Sciences (SPSS) software (version 16 for windows). A descriptive statistics including mean and standard deviation was obtained for all parameters. Analysis of covariance (ANCOVA) and test of normality (Shapiro–Wilk test) were used. Paired sample t-test was used to compare the pretest and posttest data in each group. Comparison between middle-aged and young adults has shown that MIIT causes significant increase of ALT levels in young adults. There is no significant difference between middle-aged and young adults on other variables. Also paired sample t-test shows that ALP was decreased in both groups.How to cite this articleRohollah V, Sedigheh K, Yadollah M, Rahmatollah K, Mojtaba M. Effects of Age on Liver Enzyme Levels of Obese Men following Moderate-intensity Interval Training. Euroasian J Hepato-Gastroenterol 2016;6(2):131-133.
Objective: The study aimed to determine the effect of eight weeks high intensity interval (HIIT) and sub-maximal continuous trainings on plasma betatrophin level in diabetic rats treated with metformin. Materials and Methods: In this experimental study, 42 diabeticwistar rats were divided into six groups (n=7): diabetic control (C), diabetic control + metformin consumption(C+M), diabetic HIIT, diabetic HIIT + metformin (HIIT+M), diabetic sub-maximal continuous training (SMCT), and diabetic sub-maximal continuous training + metformin (SMCT+M). Metformin was given 150 mg/kg/day by gavage every day, 48 hours after the end of the last training session, the rats were sacrificed. Then blood glucose and glycated hemoglobin (HbA1c) levels were measured. One-way ANOVA test was used for statistical analysis of data. Results: The level of plasma betatrophin was significantly different in the HIIT ( P -value= 0.01) and C+M ( P -value= 0.001) groups compared to C group. Blood glucose was significantly decreased in all training groups with or without betatrophin compared with the diabetic control group ( P -value= 0.001). However, there were no significant changes between glucose levels in HIIT, HIIT+M, SMCT, and SMCT+M groups but SMCT showed most reduction in blood glucose. Conclusion: Treatment with metformin did not change blood glucose but two types of exercise training with high and moderate intensity reduced blood glucose thus exercise can be a good alternative modality rather than taking medicine.
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