A facile strategy for the synthesis of isoxazoles has
been efficaciously
developed, which involves oxidation of propargylamines to the corresponding
oximes followed by CuCl-mediated intramolecular cyclization of the
latter. This protocol shows a straightforward way to construct a series
of isoxazole cores with a wide range of functional group compatibility.
Meanwhile, a gram-scale experiment and synthetic applications can
be successfully operated.
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