Animal welfare is a multifaceted issue of international and state policy, which requires a socio-economic, religious, and cultural approach, must consider international trade features, and must correspond to the vector of development of modern society. The new global plans and challenges of the animal protection community are to help feed the world healthily and sustainably that takes face the needs of people and is safe for animals. The protection and provision of animal welfare depend on the species differences of agricultural and productive animals, which are determined by physiological, biochemical, and behavioral factors, as well as on the differences between climatic zones, which are analyzed in the article. Modern animal husbandry systems must meet the latest knowledge about stress and be based on the science of ethology, comply with the concept of the “Five freedoms” of the welfare of productive animals, based on which a system of clear standards of animal welfare has been developed and implemented as a component of national and international public policy, commerce, and trade. However, animal welfare science continues to develop and deepen our understanding of the interaction between humankind and agricultural species by integrating ethological, physiological, and biochemical methods, methods of assessing the genotype, and its interaction with the environment into the systems for assessing the quality of animal welfare. The assessment includes measuring the artificial impact of farm conditions, microclimate, etc., on the general animal’s welfare and the interaction between individuals in the middle of a limited population. An important factor that has affected animal welfare recently is the restrictions introduced due to the COVID-19 pandemic, which affected feed supply chains, animal transportation, and limited access to high-quality veterinary services. In recent years, Ukraine has been actively implementing the international experience of animal welfare regulation into domestic legal acts. It continues harmonizing with the European Union's legal system, which covers animals' welfare during their keeping, transportation, and slaughter. A key element on the way to the practical application of the principles of animal welfare is the training of specialists – doctors of veterinary medicine, who would be aware of the importance and necessity of such approaches in their daily professional activities.
Implementation of the latest technologies of animal reproduction causes changes in the life of their body and infl uences the manifestation of sexual cyclicity. As a result, one of the main tasks of specialists of veterinary medicine is the elimination of infertility of cows and heifers and improvement of methods of regulation of their reproductive functions. In recent years, in veterinary medicine for prophylactic and therapeutic purposes individually or in combination with other agents during pregnancy, in the postpartum period for gynecological diseases, to stimulate the functions of the sexual apparatus of animals, and their farming to improve productivity eff ectively used biogenic stimulators, that are made of tissues and organs of animals and plants – tissue preparations. But remain changes of the sexual apparatus of infertile cows are not studied in their use. Therefore, the purpose of the research was to study the eff ect of tissue preparations in a complex with ihglukovit for the correction of the sexual cycle of the infertile cows in the conditions of forest-steppe in Zhytomyr region. It has been found that the using tissue preparations make from the liver and placenta and ihglukovit for cows, time successful insemination was minimal and was 47.0±5.11 days. We also observed a positive eff ect on the usefulness of the fl ow of the sexual cycle when used in complex tissue preparations from the liver and placenta, as a consequence of infertility in the cow was of 17.00±1.14 days. As all experienced animals received ihglukovit, and the period of occurrence of complete sexual cycle and the eff ectiveness of insemination of cows was diff erent, then we assume that the changes in animals are due primarily to the infl uence of tissue preparations. We believe that the using of "placental" tissue preparation make from the uterus of pregnant cows with contents was the most eff ective, because it includes biologically active substances that are similar to the sexual apparatus of a cow. Analyzing the obtained results, we recommend to apply the tissue preparation liver, placenta and ihglukovit at a dose of 20 cm3 per animal, three times with an interval of 8-10 days to correct the sexual cycle of cattle and prevention of infertility. Key words: biogenic stimulant, tissue preparation, ihglukovit, reproduction, sexual cycle, infertility, cows.
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