In the course of electrochemical generation the intermediate reaction products (free radicals of the nitro-and
investigated with reference to the mechanism of the electrochemical transformations include the antihypertensive nifedipine (corinfar, fenigidine).The interest in 1,4-dihydropyridine (DHP) derivatives has largely been due to the antioxidant properties of this type of compound, and special attention has therefore been paid to study of their electrochemical oxidation processes [1][2][3][4][5]. Among the dihydropyridines significant hypertensive activity is exhibited by the ortho-phenyl derivatives of 1,4-DHP [6], such as 2,6-dimethyl-3,5-dimethoxycarbonyl-4-(ortho-nitrophenyl)-l,4-DHP (nifedipine, fenigidine, corinfar), widely used in medical practice.The nitrophenyl derivatives of dihydropyridine are of interest from the standpoint of electrochemists as compounds containing electroactive groups capable of reduction and oxidation [7] and also from the standpoint of their use in pharmaceutical practice [8]. It is important to determine how the oxidation--reduction reactions occur and which processes determine the decomposition of these compounds.The presence of a potential intramolecular redox system in the molecule lends urgency to the problem as to whether the application of an electrochemical potential induces the intramolecular transfer of electrons in the nitrophenyl-DHP molecules or only secondary redox systems are formed as a result of electron transfer. The question is more pertinent in that the introduction of an ortho-nitropbenyl substituent at position 4 of the heterocycle leads to photochemical reduction of these compounds [9].The mechanisms of the electrochemical reduction of two series of 4-nitrophenyl derivatives of 1,4-DHP with 3,5-CN and 3,5-COOC2H 5 groups respectively at positions 3 and 5 of the DHP ring were duly compared [10]. For a number of reasons data on the electrochemical reduction of the respective analogs of the 1,2-DHP series and the more detailed results on the electrochemical reduction of the 3,5-diethoxycarbonyl derivatives of 4-nitropbenyl-l,4-DHP and also nifedipine were only published in the preprint [11]. In view of the interest of researchers in the mechanism of the electrochemical transformations in the 4-(nltrophenyl) derivatives of DHP [12], we considered k essential to publish the existing data, bringing the previously obtained results to completion.
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