The tidal Coulomb failure stresses (TCFS) on various kinds of seismic faults are calculated and their latitudinal variation characters are studied. We compute tidal Coulomb failure stresses at shock‐occurring times on 20395 earthquake faults and analyze the latitudinal distribution of various kinds of real seismic faults that are slip‐encouraged by TCFS. The results show that the features of tidal failure stress are closely correlated with fault type, fault strike and fault location. The TCFS variation properties are different on various kinds of fault during the same period. And there are obvious differences in amplitudes and signs of TCFS on same kind fault in different latitudinal regions. For normal faults, the tidal slip‐encouraged effects are outstanding in low and middle latitudinal regions; for thrust faults, the tidal slip‐encouraged effects are obvious in middle and high latitudinal region; for strike‐slip fault, the tidal slip‐encouraged effects are reducing with latitude increasing.
The adverse factors impacting the intestinal microbiota of newborns remain to be elucidated. We put forward a hypothesis that hyperoxia in combination with rituximab exhibits a synergistic effect that interferes with neonatal intestinal microbiota. Six C57BL/6J mice, aged 12 weeks and pregnant 18 days, were purchased. Their pups were breastfed and raised under a 75% oxygen or conventional environment. Low-(20 mg/kg) and high-dose (40 mg/kg) rituximab were intraperitoneally administered. Fecal genomic DNA was extracted and sequenced by a 16S rRNA platform. Severe intestinal dysbiosis in newborns were observed, whereas mild dysbiosis was caused by inducing hyperoxia alone, confirming the synergistic interference of the combination of hyperoxia and B-cell antagonist (rituximab) in neonatal intestinal microbiota disruption. Slight dysbiosis was observed in the intestinal microbiota of dams, indicating their much robust ability to confront hyperoxic conditions. The abundance of Akkermansia muciniphila was significantly and extensively altered in both pups and dams after being subjecting them to hyperoxic conditions with or without rituximab administration. In conclusion, this work demonstrated that the synergistic effect of hyperoxia and rituximab led to severe intestinal dysbiosis in newborns. More studies are recommended to explore the precise regulatory mode between hyperoxia and rituximab in intestinal microbiota.
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