Aim: It is already known that miRNAs can be differentially expressed in Alzheimer’s disease (AD). We aimed to evaluate the performance of miRNAs from blood as potential biomarkers for AD. Materials & methods: MEDLINE, PubMed and Embase were searched for studies about peripheral blood miRNAs that could discriminate patients with AD from cognitively normal controls. The data regarding the specificity and sensitivity were extracted. STATA 14.0 was used to analyze the data. Results: Ten studies containing 770 AD and 664 normal controls. The analysis showed that miRNAs presented excellent diagnostic performance and the overall sensitivity was 0.80 (95% CI: 0.75–0.83), specificity was 0.83 (95% CI: 0.78–0.87) and diagnostic odds ratio was 14 (95% CI: 11–19). Subgroup analysis suggested that the Caucasian group and blood group showed a better performance in AD diagnosis and the diagnostic odds ratio was 42 and 34, respectively. Conclusion: This meta-analysis showed that miRNAs may be a promising biomarkers for AD.
Photonic
crystals (PCs) have emerged as a promising electrochemiluminescence
(ECL) matrix in the domain of immunoassay. Making maximum use of light
manipulation properties of PCs is highly desired for improving the
sensitivity. In this work, we proposed a band-edge effect-induced
ECL enhancement strategy based on silica inverse opal PCs (SIOPCs).
By fine-tuning the lattice constant and carefully calibrating the
stopband position, we found that the band edge of the stopband exerted
significant influences on the ECL intensity and spectral distribution.
The high density of states at the blue edge of the photonic band gap
increased the radiative transition probability of ECL emitters and
enhanced the photon extraction during propagation, giving rise to
∼20-fold ECL signal amplification accompanied by a redistributed
ECL spectrum for the Ru(bpy)3
2+-TPrA system.
In combination with the intrinsic structural superiority, like large
specific surface area and interconnected macropores, the developed
SIOPC electrode was successfully applied in constructing a sandwich-type
immunosensor. The fabricated immunosensor displayed a very low detection
limit of 0.032 pg/mL and a wide linear range of 0.1 pg/mL–150
ng/mL for a carcinoembryonic antigen assay, showing its potential
application in disease diagnosis.
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