A straightforward method for the conversion of a low-cost
carbohydrate
(d-fructose) into an important carbohydrate building block
(2-deoxy-l-ribose) is reported. This methodology involves
a novel radical cyclization followed by a fragmentation reaction,
selective enzymatic hydrolysis using a lipase, and oxidative cleavage
of the vicinal diol. This method uses the cheapest starting material
and employs the shortest synthetic route (7 steps) for converting
a d-sugar into 2-deoxy-l-ribose.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.