Various studies have manifested that microRNAs (miRNAs) are involved in the modulation of the occurrence and development of osteosarcoma (OS). However, whether miR-22-3p is associated with OS growth remains unclear. In the study, the potential molecular mechanisms of miR-22-3p in OS was explored. It was affirmed that miR-22-3p was associated with distant metastasis and tumor size in OS patients, and reduced in OS tissues and cells while transcription factor 7-like 2 (TCF7L2) was elevated. Elevated miR-22-3p repressed OS cell progression, and the Wnt/β-catenin pathway, while elevated TCF7L2 was opposite. MiR-22-3p targeted TCF7L2 in OS. In functional rescue experiments, knockdown of miR-22-3p on OS progression and promotion of Wnt/β-catenin were reversed by simultaneous knockdown of TCF7L2. Transplantation experiments in nude mice showed that elevated miR-22-3p repressed OS tumor growth and decreased TCF7L2, Wnt and β-catenin. Shortly, this study suggest that miR-22-3p refrains the Wnt/β-catenin pathway by targeting TCF7L2 and thereby preventing OS deterioration. MiR-22-3p/TCF7L2 axis is supposed to be a candidate molecular target for future OS treatment.
Corrosion protection of reinforcing steel in concrete is an urgent task in modern society. Use of corrosion inhibitors in concrete is an effective, simple, and economical method for protecting reinforcing steel from corrosion. Mixed corrosion inhibitors usually perform better than a single inhibitor in actual reinforced concrete systems because of their synergistic inhibition effects. In recent years, environmentally friendly corrosion inhibitors have attracted increasing attention from corrosion researchers. Diisooctyl sebacate and sodium D-gluconate are environmentally friendly organic corrosion inhibitors, and ZnSO4 is an inorganic cathodic inhibitor, they may form an innovative, nontoxic, and pollution-free mixed corrosion inhibitor to control reinforcing steel corrosion. Additionally, diisooctyl sebacate and sodium D-gluconate serve as absorption-type inhibitors, and ZnSO4 acts as a precipitation-type inhibitor. We hypothesized that their combination might show a good synergistic corrosion inhibition effect on reinforcing steel. In this study, we developed a diisooctyl sebacate-based mixed corrosion inhibitor that includes D-gluconate and ZnSO4 and investigated its synergistic inhibition effects on reinforcing steel (Q235 steel) corrosion in a simulated polluted concrete pore solution. The reinforcing steel corrosion behavior and the properties of the mixed corrosion inhibitor were studied by polarization curve measurements, electrochemical impedance spectroscopy tests, and surface analysis methods (scanning electron microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy). The results indicated that the reinforcing steel in the simulated polluted concrete pore solution (pH 11.00, 0.5 mol•L −1 NaCl) was in an active dissolving state and that localized corrosion took place. The mixed corrosion inhibitor, consisting of diisooctyl sebacate (59 mmol•L −1 ), sodium D-gluconate (0.5 mmol•L −1 ), and ZnSO4 (1.5 mmol•L −1 ), had an obvious and powerful inhibition effect. Its inhibition efficiency reached 96.8% and 90.0% in the simulated polluted concrete pore solution and the cement mortar, respectively. The mixture of diisooctyl sebacate with sodium D-gluconate and ZnSO4 acted as a mixed-type inhibitor and effectively controlled both anodic and cathodic reactions of the steel corrosion.
Corrosion behavior of reinforcing steel in the simulated polluted concrete pore (SPCP) solutions and the inhibition effect of NaNO 2 and D-sodium gluconate on the steel corrosion were studied by polarization curve measurements and electrochemical impedance spectroscopy (EIS). The results indicated that the compound inhibitor contained 5 g L -1 NaNO 2 and 0.01 M D-sodium gluconate could produce a strong inhibition effect for the steel in the solution with pH 11.00 and 3.5% NaCl, and its inhibition efficiency reached about 99.0%. The compound inhibitor mainly acted as an anodic corrosion inhibitor, and had an obvious synergistic effect on the corrosion inhibition of reinforcing steel.
To explore effects of air humidity on properties of JO-9159 explosive, the amorphous model of six components was constructed by Materials Studio software, periodic molecular dynamics simulation was conducted at seven kinds of relative humidity ranging from 10% to 70% for (001), (010), (100) crystal planes of JO-9159 explosive in COMPASS force field and NVT ensemble. Mechanical properties, sensitivity and detonation properties of JO-9159 explosive were researched basing on equilibrium trajectory of model. The results show that with the increasing of relative humidity, the total adsorption energy increases. The adsorption capacity of JO-9159 explosive for H2O is much stronger than O2 and N2; The breaking strength has a decreasing trend with the humidity increases and the stiffness and hardness of JO-9159 explosive are smaller at 30% and 40% relative humidity; At 30% relative humidity, the sensitivity of JO-9159 explosive is highest and detonation properties are weakest, while the detonation properties are strongest at 20% relative humidity.
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