followed by filtration of the desired salt and vacuum drying.,' Then, 4.5 g (61 "01) of 2-butanol and 2.3 g (20 "01) of the formamidinium salt were stirred under reflux for 21 h. The mixture was cooled to room temperature, washed with 15 mL of Et,O, and concentrated under vacuum. The residue was dissolved in 2 mL of MeOH and chromatographed over silica gel with 1 3 1 CH2Cl2/MeOH eluent. Weobtained 1.29 g (8.4 mmol, 42%) of isouronium salt 8 as a highly hygroscopic, glassy solid (under vacuum), that fused to a slightly yellow oil in the atmosphere. J = 6 Hz, CHCH,); 1.45-1.65 (m, 2 H, CH,); 4.75-4.95 (m, 1 H, CH); 8.67 (br s, 4 H, 2N+H2). to (S)-8 were carried out analogously. Detailed descriptions of the optical rotations of these materials appear in the text.3-(2-Butoxy)-3-chlorodi.ziriw (9). The Graham oxidationI8 was carried out on 1.29 g (8.4 mmol) of isouronium salt 8. The salt was dissolved in 5 mL of DMSO, then, 15 mL of pentane and 0.1 g (2.4 "01)of LiCl were added. The mixture was stirred and cooled to 5 ' C while 220 mL of 12.5% aqueous NaOCl was added dropwise. The reaction temperature was kept at 10-13 ' C during the addition. Stirring was continued for 20 min at 13 OC after addition of the hypochlorite. Then, 150 mL of ice water was added, the pentane layer was separated, the aqueous layer was extracted with 10 mL of pentane, and the organic extracts were combined. The resulting pentane solution of 9 was washed with 50 mL of brine and then dried over CaCI,. Higher boiling solvents (MeCN, I-butanol) could then be added and pentane removed at 0 ' C under aspirator vacuum, to afford solutions of diazirine 9 in other solvents. The UV and NMR spectra of 9 are described above; it was too unstable to chromatograph. (a-9 was prepared from (S)-8 in the same way.(neat)), 6.2 mL (5.0 g, 67.5 mmol), and 4.6 mL of dichlorophenyl-'H NMR (DMSO-d6): 0.84 (t, J = 7 Hz, 3 H, CHzCHJ; 1.21 (d, (~)-2-chlorobut.ne (12). (R)-(-)-2-Butanol (AIdrich, [aI2'D -12.8' Abstract: We have developed an integrated approach for investigating the 'bioactive conformations" of the main chain and side chains for the somatostatin analog ~[Pro~-Phe~-~-Trp~-Lys~-Thr~~-Phe'~]. A series of analogs have been synthesizedincorporating a-methylated and 8-methylated residues at positions 7,8, and 11. These analogs display dramatic differences in in vitro binding affinities for somatostatin receptors. Using 500-MHz 'H NMR and computer simulations, we have assessed the effect of main chain and side chain chiral methylations on the overall structure. The analyses of the changes of side chain topologies and subsequent binding affinities in the 8-methylated analogs have provided definitive evidence about the 'bioactive conformation" of the side chains of Phe7, Trp8, and Phe". The analyses of the a-methylated analogs have defined a 'folded" feature for the peptide backbone. From this study, we have proposed a binding 'pocket" for somatostatin analogs which consists of the side chains of Trp' and Lys9, the peptide backbone, and the side chain of Phe" in a...

As a fundamental work for pavement maintenance management, the evaluation on asphalt pavement performance is the premise of determining the maintenance time and strategy. Aiming at the shortcomings of traditional TOPSIS model, an improved TOPSIS method is proposed to make comprehensive assessment on asphalt pavement performance. Instead of the Euclid distance, the vertical distance between the evaluation object and positive ideal solution is taken as the basis for alternatives ranking. A case study is carried out, indicating that this approach is rational and feasible. The result can provide a certain reference for the road management department to make optimal decision.

In recent years, a lot of research practices have been done on improving the quality of subgrade construction and solving the differential settlement of subgrade. Therefore, key construction technology for highway on soft foundation is very important. This paper analysis common engineering problems on soft foundation and the development status for soft soil treatment technology, then build up the technology trends on it.

According to the definition of green supply chain management, giving its connotation in detail in low-carbon economy model. Analyzing the enterprise impact on the environment protection and sustainable development, reviewing the implementation of the green supply chain management in developed countries and regions enterprise in low-carbon economy model, studying on how to implement green supply chain management in the enterprise, and proposing our country developing the green supply chain management rapidly. Low-carbon economy requires the use of ecological rules to guide the human society and economic activities. Our country’s enterprise can enhance the benefit unceasingly and can make a greater contribution to our country economic and social development.

Project controlling information management system (PCIMS) is an important management facility and means for the construction of large-scale hydraulic engineering. Based on the analysis of construction management features for large-scale hydraulic engineering, the general design goal of PCIMS is put forward. The structure of PCIMS for large-scale hydraulic engineering is concretely designed and analyzed, which is consisted of five parts, including the account management module, database, input module, data processing module and output module. The key technologies in the process of developing PCIMS are also discussed，such as the technology of data warehouse, the real-time technology of the system and the comprehensive integration technology of various components. Due to the establishment of PCIMS for large-scale hydraulic engineering, a convenient information interaction platform is provided for all the project participants. As a result, the accuracy and timeliness of the information exchange is improved, that is benefit for the owners to make correct decision.