(Eur J Anaesthesiol. 2020;37:309–315)
Phenylephrine is considered the first-line therapy for the prevention of hypotension in obstetric anesthesia. However, phenylephrine may cause bradycardia and decreased maternal cardiac output. Norepinephrine has been proposed as an alternative to phenylephrine for treating or preventing hypotension during cesarean delivery. The primary goal of this study was to determine the effective dose (ED) of norepinephrine to prevent spinal-induced hypotension during cesarean delivery. The secondary aim was to examine adverse events and neonatal outcomes seen with various infusion rates of norepinephrine.
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