Purpose: To investigate the effects of huperzine A (HupA) on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia.Methods: Thirty-six Sprague Dawley rats (20-22 months old) were randomly divided into control, isofluran, and isoflurane+HupA groups; 12 rats in each group. The isoflurane+HupA group was intraperitoneally injected with 0.2 mg/kg of HupA. After 30 min, isoflurane inhalation anesthesia was performed in the isoflurane and isoflurane+HupA groups. After 24 h from anesthesia, Morris water maze experiment and open-field test were performed. Hippocampal inflammatory and neurotrophic factors were determined.Results: Compared with isoflurane group, in isofluran+HupA group the escape latency of rats was significantly decreased (P < 0.05), the original platform quadrant residence time and traversing times were significantly increased (P < 0.05), the central area residence time was significantly increased (P < 0.05), the hippocampal tumor necrosis factor α, interleukin 6 and interleukin 1β levels were significantly decreased (P < 0.05), and the hippocampal nerve growth factor, brain derived neurotrophic factor and neurotrophin-3 levels were significantly increased (P < 0.05). Conclusion:HupA may alleviate the cognitive impairment in rats after isoflurane anesthesia by decreasing inflammatory factors and increasing hippocampal neurotrophic factors in hippocampus tissue.Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia Cai Y et al. Acta Cir Bras. 2019;34(12):e201901205 Determination of hippocampal inflammatory and neurotrophic factorsAfter the behavioral test, the rats were executed by cervical dislocation. The head was cut off and the Effects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia Cai Y et al. Cir Bras. 2019;34(12):e201901205 ActaEffects of huperzine A on hippocampal inflammatory response and neurotrophic factors in aged rats after anesthesia Cai Y et al.
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