A new heritable disorder of connective tissue called the Wrinkly Skin Syndrome is described, This syndrome appears to be transmitted as an autosomal recessive disorder. Clinically it is characterized by the appearance at birth of wrinkled skin about the hands and feet together with an increase in the number of creases on the ventral surfaces. Other altered connective tissue manifestations are present. A discussion is given which distinguishes the clinical and genetic features of this syndrome from those found in similar known heritable disorders of connective tissue.
In 1933 McIntosh (Holt and McIntosh, 1933) described abnormal findings in a girl who had hereditary ectodermal dysplasia, associated with polydactylism and chondrodystrophy. Ellis and van Creveld (1940) described two additional cases, thereby concluding that this was a new syndrome with which their names have since been eponymously associated.Since then reports on the subject have grown considerably (Gatto
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