Purpose To evaluate the versatility of the collagen membrane as both drug carrier and biologic dressing material to cover the raw wounds created after the surgical excision of fibrotic bands in oral submucous fibrosis. Materials and Methods The study comprises of ten patients. The patients of age group 20 to 50 years were selected. The collagen is reconstituted by injecting with dexamethasone and placentrix solution leaving a small overlap on to the remaining mucous membrane and the graft is sutured. Preoperative and post operative assessment was done regarding the improvement in mouth opening, decrease in burning sensation, change in colour of oral mucosa and clinically grading the extent of lesion. Results The results were found appreciable in seven patients while in the remaining three patients it showed relapse because of inadequate physiotherapy. All the ten patients were comfortable with intra oral collagen grafting. The collagen remained moist and supple intraorally, and remained in close contact with the underlying tissues, providing a strong mechanical barrier. The material was effective in attaining haemostasis, relieving pain and preventing extensive contracture. Conclusion In this study of short duration, the nature of collagen membrane was observed as both biological dressing material and drug carrier. It was found as a very suitable alternative to the other graft material mentioned for the repair of defects in the mucous membrane created by surgical excision of fibrous bands in oral submucous fibrosis.
Lymphomas are malignant neoplasms arising from lymphocytes B cell or T cell that affects mainly lymph nodes, spleen and other non hematopoietic tissues. They are classified as Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Diffuse large B-cell lymphoma (DLBL) is the most common variant of non-Hodgkin's lymphomas and frequently involves extranodal sites. In the oral soft tissues lesions can occur as hard and diffuse tumors involving oral vestibule, gums and posterior region of the hard palate. Most lymphomas, including DLBL arise from B cells are characterized by diffuse population of large cells with cleaved or non cleaved oval nuclei. Both histopathlogical and immunohistochemical (IHC) analysis were strongly advisable for proper management and prognosis. We hereby report a rare case of Diffuse large B-cell variant of non-Hodgkin's lymphoma in a male patient of age 50yrs in left upper buccal vestibule.
A 72-year-old man from rural South Africa presented with a one-year history of lower urinary tract symptoms (LUTS) and intermittent right scrotal pain. His International Prostate Symptom Score (IPSS) (a questionnaire-based screening tool to quantify, track and manage the symptoms of BPH/LUTS) was 19, indicating moderately severe symptoms. 1 He denied any constitutional symptoms and there was no significant medical or surgical history. He had no known TB contacts nor any occupational risk factors to develop TB. He was not on corticosteroids. The general and systemic examination was unremarkable. The patient had mild right hemi-scrotal swelling with no skin changes or sinuses and no clearly definable mass on urogenital examination, and digital rectal examination (DRE) findings revealed a hard, nodular prostate. His prostate specific antigen (PSA) was 37.99 ug/L and urinalysis showed a sterile pyuria. A clinical suspicion of underlying 'prostate cancer' was formulated in light of the DRE and PSA, so a trans-rectal ultrasound guided (TRUS) prostate biopsy was performed. Histology showed extensive necrotising granulomatous inflammation suggestive of an active mycobacterial infection, although acid-fast bacilli (AFB) were not detected and PAS staining showed no fungal infection. (Figure 1 B-D). There were no pre-neoplastic or neoplastic features. Despite the absence of AFB on the slides assessed, the associated features and regional residence led to a working diagnosis of TB prostatitis and the patient was investigated accordingly. An HIV ELISA test was non-reactive. His chest
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