Objectives: To investigate the effects of medium-and long-chain triacylglycerol (MLCT) on blood triglyceride (TG) in Chinese hypertriglyceridemic subjects. Methods: A double-blind controlled clinical trial was carried out, in which 112 subjects with hypertriglyceridemia were randomly divided into two dietary oil groups: (1) long-chain triacylglycerol (LCT) and (2) MLCT. All subjects were requested to ingest fixed energy and to continue their normal activity levels, and to consume LCT or MLCT oil at 25-30 g daily during the study period. Anthropometric measurements of body weight, body mass index (BMI), body fat, body fat percentage, waist and hip circumference (WC and HC), areas of subcutaneous and visceral fat by computed tomography scanning and blood biochemical markers were measured at the beginning and end of the study. Results: There were 50 and 51 subjects left in LCT and MLCT groups, respectively. There were no significant differences in daily intake of energy, protein, fat and carbohydrate, as well as the daily physical activity between the two groups during the study. After 8 weeks, MLCT group showed a significant decrease in body weight, BMI, WC, HC, ratio of WC and HC, body fat, body fat percentage and subcutaneous fat when compared with the initial values. The decrease in body weight, BMI, WC, body fat and subcutaneous and visceral fat was significantly greater in MLCT group than that in the LCT group. Furthermore, the serum concentrations of TG in MLCT group were significantly lower than those in the LCT group. Conclusions: Consumption of MLCT may reduce body weight, body fat and blood TG in hypertriglyceridemic subjects under an appropriate dietary regime.
Prevalent worldwide, Helicobacter pylori infection can increase risk of gastric cancer and is associated with the occurrence of a variety of human diseases, including lymphoma and autoim-mune disorders [1,2]. H. pylori infection is most common in the stomach, and patients with it may have heartburn, epigastric pain, dyspepsia, and other nonspecific symptoms, which are easily overlooked in a majority of cases [3]. Diagnosis of H. pylori infection can be made based on judgment of the clinical manifestation, detection of a specific antibody in serum,
Sepsis‐induced myocardial depression (SIMD) is common in pediatric intensive care units and seriously threatens children's health. Recently, long noncoding RNAs (lncRNAs) have been showed to play important roles in various diseases; however, its role in SIMD is unclear. In this study, we used lipopolysaccharide (LPS)‐treated rats and H9c2 cardiomyocytes to mimic SIMD in vivo and in vitro. We found that the expression of a novel lncRNA, we named lncRNA‐AABR07066529.3, was elevated in LPS‐induced rat heart tissue and H9c2 cardiomyocytes. In addition, LPS‐induced inflammation, apoptosis, and pyroptosis were significantly exacerbated after lncRNA‐AABR07066529.3 knockdown. Moreover, we found that myeloid differentiation factor 88 (MyD88) was upregulated in LPS‐treated groups and was inhibited by lncRNA‐AABR07066529.3. Besides, MyD88 knockdown abolished lncRNA‐AABR07066529.3 silencing effects on inflammation, apoptosis, and pyroptosis induced by LPS in H9c2 cardiomyocytes. In our study, we found lncRNA‐AABR07066529.3 exerted protective effects on LPS‐induced cardiomyocytes by regulating MyD88 and might serve as a potential treatment target for SIMD.
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