Neutron star-neutron star mergers are known to be associated with short gammaray bursts 1-4 . If the neutron star equation of state is sufficiently stiff, at least some of such mergers will leave behind a supramassive or even a stable neutron star that spins rapidly with a strong magnetic field (i.e., a magnetar) 5-8 . Such a magnetar signature may have been observed as the X-ray plateau following a good fraction (up to 50%) of short gamma-ray bursts 9, 10 , and it has been expected that one may observe short gamma-ray burst-less X-ray transients powered by double neutron star mergers 11, 12 . A fast X-ray transient (CDF-S XT1) was recently found to be associated with a faint host galaxy whose redshift is unknown 13 . Its X-ray and host-galaxy properties allow several possible explanations including a short gamma-ray burst seen off axis, a low-luminosity gamma-ray burst at high redshift, or a tidal disruption event involving an intermediate mass black hole and a white dwarf 13 . Here we report a second X-ray transient, CDF-S XT2, that is associated with a galaxy at redshift z = 0.738 14 .The light curve is fully consistent with being powered by a millisecond magnetar. More intriguingly, CDF-S XT2 lies in the outskirts of its star-forming host galaxy with a moderate offset from the galaxy center, as short bursts often do 15,16 . The estimated event rate density of similar X-ray transients, when corrected to the local value, is consistent with the double neutron star merger rate density inferred from the detection of GW170817 1 .Upon the completion of the deepest X-ray survey to date, the 7 Ms Chandra Deep Field-

Our results provide novel evidence for the increase of IGF-1 in tibia bone marrow, which is responsible for the up-regulation of TRPV1 expression and function in the peripheral nerves of bone cancer pain rats.

Converging lines of evidence demonstrate a vagally mediated antinociceptive pathway in animals undergoing acute visceral insults, the contribution of this system to visceral pain following chronic noxious stimuli is unknown. 5-HT(3) receptor (5-HT(3)Rs) on spinal afferents are crucially involved in nociceptive processing, the role of 5-HT(3)Rs on vagal afferents is unclear. The aim of the present study was to determine the contribution of vagal afferents to visceral nociception in rats undergoing chronic luminal allergen stimulation and whether it involves vagal 5-HT(3)Rs. Sensitized rats received chicken egg albumin (EA, 1 mg mL(-1)) in drinking water for 2 weeks (day 1-14). Visceromotor response (VMR) to colorectal distension [colorectal distension (CRD), 60 mmHg] and the levels of mRNA encoding 5-HT(3)R (including 3A and 3B subunits) in the nodose ganglia (NG) were evaluated on day 2, 4, 8 and 15. Chronic EA challenge induced gradually increased visceral nociception, with a peak on day 15. Subdiaphragmatic vagotomy or functional deafferentation with capsaicin abolished this time-dependent manner, inducing hyperalgesia from day 2, lasting to day 15. Intraluminal infusion of a 5-HT(3)R antagonist (granisetron), whether alone or infused after local mucosa anaesthetic with 1% lidocaine, mimicked the effects of vagotomy. The mRNA levels for 5-HT(3B) or 5-HT(3A) subunit in the NG showed an opposite time-course to that of visceral pain, which increased from day 2, then decreased gradually to levels lower than those of controls. Our results demonstrate a time-dependent vagal afferent modulation of chronic allergen-sensitized visceral hyperalgesia, which may involve a 5-HT(3)R pathway.

Lemnaceae (duckweeds) are widely distributed aquatic flowering plants. Their high growth rate, starch content and suitability for bioremediation make them potential feedstock for biofuels. However, few natural duckweed resources have been investigated in China, and there is no information about total fatty acid (TFA) and triacylglycerol (TAG) composition of duckweeds from China. Here, the genetic diversity of a natural duckweed population collected from Lake Chao, China, was investigated using multilocus sequence typing (MLST). The 54 strains were categorised into four species in four genera, representing 12 distinct sequence types. Strains representing Lemna aequinoctialis and Spirodela polyrhiza were predominant. Interestingly, a surprisingly high degree of genetic diversification within L. aequinoctialis was observed. The four duckweed species revealed a uniform fatty acid composition, with three fatty acids, palmitic acid, linoleic acid and linolenic acid, accounting for more than 80% of the TFA. The TFA in biomass varied among species, ranging from 1.05% (of dry weight, DW) for L. punctata and S. polyrhiza to 1.62% for Wolffia globosa. The four duckweed species contained similar TAG contents, 0.02% mg · DW(-1). The fatty acid profiles of TAG were different from those of TFA, and also varied among the four species. The survey investigated the genetic diversity of duckweeds from Lake Chao, and provides an initial insight into TFA and TAG of four duckweed species, indicating that intraspecific and interspecific variations exist in the content and composition of both TFA and TAG in comparison with other studies.

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Ethanol-dichloromethane crude extract from peel of pear (Pyrus bretschneideri Rehd. cv. Pingguoli) was separated by thin layer chromatographic plates and bioassayed with conidia of Alternaria alternata. The inhibition zones differed significantly in retention factor (R f ) at expanding stage, harvest time and after 100 days of cold storage. The compounds in the inhibition zones were isolated and identified with gas chromatography and mass spectroscopy. Palmitate methyl, oleic acid methyl, linolenic acid methyl and squalene were present at all stages. The concentration of these chemicals was the highest in expanding stage fruit peel and decreased rapidly with fruit development. It is suggested that these compounds may be the main antifungal compounds in the growing fruit. The phthalate alkyl esters occurred at relatively higher concentrations in pear peel at harvest and after 100 days of cold storage. Six phthalate alkyl esters were identified from peel of pear fruit after 100 days of cold storage. It is also supposed that these esters may be the antifungal compounds in postharvest pear.

Mouse platelet basic protein (CXCL7/mPBP) was cloned from thymic stromal cells and further identification indicated that it was expressed in thymic monocytes/macrophages (Mo/Mphis). Recombinant mPBP was chemoattractive for target cells of polymorphonuclear leucocytes, peritoneal Mo/Mphis and splenic lymphocytes with distinct potencies. CXCR2 was identified to be a cognate receptor for mPBP. Mouse thymocyte subsets of CD4-CD8- double-negative (DN), CD4+CD8+ double-positive (DP), CD4+CD8- single-positive (CD4SP) and CD4-CD8+ single-positive (CD8SP) expressed cell surface CXCR2 with different positive percentages and expression levels. mPBP was chemoattractive for thymocyte subsets with the potency order DN>DP> CD8SP>CD4SP, consistent with the levels of CXCR2 expressed on the respective cells. Thus, mPBP in thymus is functionally redundant with chemokine CXCL12/ SDF-1. Moreover, our finding that thymic Mo/Mphis can produce mPBP implies that they may have other functions apart from acting as scavengers in thymus.

Identifying the processes that determine the initial mass function of stars (IMF) is a fundamental problem in star formation theory. One of the major uncertainties is the exact chemical state of the star forming gas and its influence on the dynamical evolution. Most simulations of star forming clusters use an isothermal equation of state (EOS). We address these issues and study the effect of a piecewise polytropic EOS on the formation of stellar clusters in turbulent, selfgravitating molecular clouds using three-dimensional, smoothed particle hydrodynamics simulations. In these simulations stars form via a process we call gravoturbulent fragmentation, i.e., gravitational fragmentation of turbulent gas.To approximate the results of published predictions of the thermal behavior of collapsing clouds, we increase the polytropic exponent γ from 0.7 to 1.1 at some chosen density n c , which we vary from from 4.3 × 10 4 cm −3 to 4.3 × 10 7 cm −3 . The change of thermodynamic state at n c selects a characteristic mass scale for fragmentation M ch , which we relate to the peak of the observed IMF. We find a relation M ch ∝ n −0.5±0.1 c . Our investigation supports the idea that the distribution of stellar masses largely depends on the thermodynamic state of the star-forming gas. The thermodynamic state of interstellar gas is a result of the balance between heating and cooling processes, which in turn are determined by fundamental atomic and molecular physics and by chemical abundances. Given the abundances, the derivation of a characteristic stellar mass may thus be based on universal quantities and constants.