Melt-Sonocrystallization is a novel particle engineering technique having applications in pharmaceuticals. The present study was to investigate the suitability of the melt sonocrystallization technique in order to modify the processability properties along with solubility and drug release of non-steroidal antiinflammatory drug Ketoprofen which is class II drug. Melt sonocrystallized Ketoprofen agglomerates were prepared by probe ultrasonicator by varying the sonication time (1, 2 and 3 min) and level of amplitude (65, 75 and 85%). The meltsonocrystallized Ketoprofen agglomerates were prepared at different time and amplitude, using probe ultrasonicator. The prepared agglomerates has shown an increase in the solubility and the drug release may be due to formation of porous agglomerates witnessed in Scanning Electron Microscopic photographs. These results were well supported by Differential Scanning Calorimetry and X-ray Powder Diffraction, which has indicated the decrease in drug crystallinity. As sonication time and amplitude increased, Study of Infra-red Spectroscopy revealed that no chemical transition of Ketoprofen has occurred during Melt sonocrystallization. Thus Melt sonocrystallization is a promising cost effective technique that may give a powder improved processability properties with improvement in solubility and drug release much needed for BCS class II drugs.
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