Four new cases of the Wolf-Hirschhorn syndrome are presented, two of which were due to t(4;22)mat. Review of the literature (more than 100 cases of the Wolf-Hirschhorn syndrome) showed that 13 % of all the reported cases were not mutations but segregations of parental chromosomal aberrations, primarily translocations. Similar data were obtained previously for other deletions (5p--, 18p--, 1Sq-). Analysis of data on some "new" deletion syndromes (4q--, 8p-, 9p-, lop-, l l p -, llq-) revealed that 14.5% were inherited cases. Thus, all human autosomal deletions have virtually the same genetic pattern.
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