2 cases of acute lymphoblastic leukaemia (ALL) of childhood in association with Gaucher's Disease (GD) are presented, which are the first to be described. One of them is a common non‐B non‐T cell ALL and the other is at T‐cell ALL. The association of GD with benign and malignant B‐cell proliferation has recently been described. It is suggested that chronic stimulation of the immune system by the accumulated glucocerebroside may predispose to B cell proliferation.

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SUMMARYInfection of mice with murine cytomegalovirus (CM V) presents a model for the study of the role of the immune system in the pathogenesis of human CM V. We performed adoptive transfer experiments to evaluate the prospects for enhancing the anti-viral potential of murine CMV immune spleen cells by THF-y2. Adult BALB/c mice resistant to murine CMV become highly susceptible following immunosuppression by cyclophosphamide. Recipient mice were injected with murine CMV and cyclophosphamide concomitantly, and 24 h later adoptive transfers of syngeneic immune spleen cells were performed. We showed that passive transfers of murine CM V immune spleen cells prevented the development ofa fatal disease in 38'H. of the recipient mice. Daily injections of murine CMV immune donor mice with THF->'2 enhanced considerably (93%) the therapeutic potential of virus-specific immune cells. These experiments provide direct evidence for the antiviral capacity of THF-72 through its immunomodulatory effect on immune T cells.