Fractionation of the extract of Aspergillus niger. IFB-E003, an endophyte in Cyndon dactylon, gave four known compounds naphtho-gamma-pyrones rubrofusarin B, fonsecinone A, asperpyrone B and aurasperone A, which were further investigated biologically. Rubrofusarin B was shown to be cytotoxic to the colon cancer cell line SW1116 (IC50: 4.5 microgml-1), and aurasperone A inhibitory on XO (xanthine oxidase) (IC50: 10.9 micromoll-1). Moreover, the four naphtho-gamma-pyrones exhibited growth inhibitions against the five test microbes with MICs ranging in between 1.9 and 31.2 microgml(-1). The present recognition of rubrofusarin B and aurasperone A as strong co-inhibitors on XO, colon cancer cell and some microbial pathogens is of significance for the imperative discovery of new relevant therapeutic agents.

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We proposed an unconventional Landau-Zener-Stückelberg interferometry in strongly driven two-level systems subjected to quantum noise. A general transition rate for consecutive Landau-Zener transitions was obtained, from which we could analytically calculate interference fringes. The strong low-frequency noise would detour the evolution paths, leading to asymmetric transition rates which caused unpredicted position shift of the fringes and population inversions in a two-level system.

The shallow decay phase and flares in the afterglows of gamma-ray bursts (GRBs) is widely believed to be associated with the later activation of central engine. Some models of energy injection involve with a continuous energy flow since the GRB trigger time, such as the magnetic dipole radiation from a magnetar. However, in the scenario involving with a black hole accretion system, the energy flow from the fall-back accretion may be delayed for a fall-back time ∼ t fb . Thus we propose a delayed energy injection model, the delayed energy would cause a notable rise to the Lorentz factor of the external shock, which will "generate" a bump in the multiple band afterglows. If the delayed time is very short, our model degenerates to the previous models. Our model can well explain the significant re-brightening in the optical and infrared light curves of GRB 081029 and GRB 100621A. A considerable fall-back mass is needed to provide the later energy, this indicates GRBs accompanied with fall-back material may be associated with a low energy supernova so that fraction of the envelope can be survived during eruption. The fall-back time can give meaningful information of the properties of GRB progenitor stars.

The generation of three-mode continuous-variable entanglement in a quasiperiodically optical superlattice is studied theoretically in this paper. This work is based on the previous experiment result in which three-color light generated from a quasiperiodically optical superlattice through a stimulated parametric down-conversion cascaded with a sum-frequency process. The degree of quadrature phase amplitude correlations, a nonclassical characteristic, among the three mode was discussed by a sufficient inseparability criterion for continuousvariable entanglement, which was proposed by van Loock and Furusawa.

Pseudomonas putida KT2440-JD1 is able to cometabolize benzoate to cis, cis-muconate in the presence of glucose as growth substrate. P. putida KT2440-JD1 was unable to grow in the presence of concentrations above 50 mM benzoate or 600 mM cis, cis-muconate. The inhibitory effects of both compounds were cumulative. The maximum specific uptake rate of benzoate was higher than the specific production rate of cis, cis-muconate during growth on glucose in the presence of benzoate, indicating that a benzoate derivative accumulated in the cells, which is likely to be catechol. Catechol was shown to reduce the expression level of the ben operon, which encodes the conversion of benzoate to cis, cis-muconate. To prevent overdoses of benzoate, a pH-stat fed-batch process for the production of cis, cis-muconate from benzoate was developed, in which the addition of benzoate was coupled to the acidification of the medium. The maximum specific production rate during the pH-stat fed-batch process was 0.6 g (4.3 mmol) g dry cell weight(-1) h(-1), whereas 18.5 g L(-1) cis, cis-muconate accumulated in the culture medium with a molar product yield of close to 100%. Proteome analysis revealed that the outer membrane protein H1 was upregulated during the pH-stat fed-batch process, whereas the expression of 10 other proteins was reduced. The identified proteins are involved in energy household, transport, translation of RNA, and motility.

No abstract

We theoretically show that continuous-variable genuine quadripartite entanglement can be generated by intracavity cascaded nonlinear optical interactions. The process consists of a parametric down-conversion, a sum-frequency generation of pump and signal and a sum-frequency generation of pump and idler. The characteristics of the quadripartite entanglement among the signal, the idler, and two sum-frequency modes are analyzed by applying a sufficient inseparability criterion for multipartite continuous-variable entanglement proposed by Van Loock and Furusawa. The threshold properties of the system are also discussed.