Israel is a country with low, intermediate, and high incidence of childhood IDDM. The interethnic differences in incidence are probably due to genetic factors. However, the significant increase in incidence since 1985 in the Jewish population is ascribed to thus far unidentified environmental factors. It is hypothesized that the marked increase in IDDM is due to environmental factors linked to changes in affluence and lifestyle. These may also explain the difference in incidence between the Jewish and Arab populations, the latter living more in rural areas and leading a more traditional lifestyle.
During puberty, growth and circulating SIC increase require normal GH secretion txlt the respective role of GH and sex steroids is still unsettled.This question was adressed by canparing children with low or normal GH secretion &ring PP. 28 children, with PP and similar gonadal activity, were classified into 2 groups according to their GH peak response to AITT : Grcup I > 10 ng/ml, Group I1 < 5 ng/ml. They were carpared to prepubertal hypopituitary cases (Grwp 111). Plasma SmC/IGFI was measured by RIA (m + sem).Group n CA (yr) DA (yr) cm/yr GH peak (ng/ml) SmC (U/ml) I 20 7.1 + 0.5 9.8 20.6 9 + 0.6 24 ~2 . 5 2.01 + 0.17 I1 8 8.2 + 1.1 9.5 + 1.3 6.8 + 0.6 3 50.5 0.71 + 0.14 111 7 11.3 + 1.1 6.9 20.9 1.9 + 0.5 1 + 0.3 0.07 ~0 . 0 1 Ry canparison of II/I it appears thst GH deficiency decreased the mean SmC level (p
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