clinical diagnosis (degree I-III). 141 healthy subjects from Xi'an city were chosen and matched by age and sex. The study was performed in accordance with the Declaration of Helsinki and approved by the Human Ethics Committee of Xi'an Jiaotong University. Informed written consent was obtained from each subject. The staple food (flour, rice and corn hazel) and hair from children and healthy subjects were collected. The selenium level in hair and staple food was tested with Atomic Fluorescence Spectrophotometer. Results: About 65 children which the total number of children was 1743 were KBD X-ray positive. The selenium level in hair of children from xunyi county was significantly lower than healthy subjects from Xi'an city (0.24 and 0.62 μ g/g respectively, P< 0.05). No difference was found in selenium level of staple food between children from xunyi county and the control group (P> 0.05). ConClusions: The abnormal ration of X-ray in children from xunyi county was lower than 5%. Although prevention and control measures have been implemented, the selenium level in hair of children from xunyi county was still lower. Children lived in xunyi county should intake more Se to prevent KBD.
OBJECTIVES: Assess the profile of use of immunobiological (IMB) in the service of rheumatology of a Health PlansOperator (HPO) located in Fortaleza,Ceará, Brazil. METHODS: This is a descriptive and retrospective study. The data was collected from the medical skills performed in the rheumatology service, as well as the revision of patients' charts in use of IMB from 2012 to 2016. RESULTS: Were analyzed 354 patients, with female predominance, 68.36% (n = 242) and the median of age was 50 years. The pathologies of higher incidence were rheumatoid arthritis with 42.37% (n = 150), ankylosing spondylitis with 39.27% (n = 139) anderythroderma arthritis with 8.76% (n = 31). 487 therapeutic schemes were used during the period. The inhibitors of the tumor necrosis factor (anti TNF) were the most used in relation to the other classes, representing 73.10% (n = 356). The other classes were interleukin-6 (12.32%) inhibitors, depletor of lymphocytes B (6.98%); T lymphocyte inhibitor (6.16%); interleukin-17 inhibitor (1.03%); interleukin inhibitor-12/23 (0.41%). The most prominent anti TNF were the infliximab, the adalimumab and the golimumabe representing 21.36%, 19.51% and 11.50% of the use, respectively. CONCLUSIONS: The knowledge of the profile and patient care information is the basis for any planning strategy. The high cost of these medicines shows the need for multiprofessional auditing to evaluate the correct use and impact that the IMBs possess in the healthcare provider. This is important to plan and offer the best care of the patient and intervene when necessary.
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