and Telecommunications under the supervision of Prof. Wenzhen Lv. His research interests focus on design, synthesis, and optical properties study of halide perovskite nanocrystals.
In recent year, substantial progress has been made in the synthesis of colloidal CsPbX3 (X = Cl, Br, I) nanocrystals (NCs). However, the anion exchange reaction always synthesize the CsPbCl3...
Coronavirus Disease 2019 (COVID-19), caused by the novel coronavirus, has spread rapidly across China. Consequently, there is an urgent need to sort and develop novel agents for the prevention and treatment of viral infections. A rapid structure-based virtual screening is used for the evaluation of current commercial drugs, with structures of human angiotensin converting enzyme II (ACE2), and viral main protease, spike, envelope, membrane and nucleocapsid proteins. Our results reveal that the reported drugs Arbidol, Chloroquine and Remdesivir may hinder the entry and release of virions through the bindings with ACE2, spike and envelope proteins. Due to the similar binding patterns, NHC (β-d-N4-hydroxycytidine) and Triazavirin are also in prospects for clinical use. Main protease (3CLpro) is likely to be a feasible target of drug design. The screening results to target 3CL-pro reveal that Mitoguazone, Metformin, Biguanide Hydrochloride, Gallic acid, Caffeic acid, Sulfaguanidine and Acetylcysteine seem be possible inhibitors and have potential application in the clinical therapy of COVID-19.
Poly(3,4-ethylenedioxythiophene):polystyrenesulfonate
(PEDOT:PSS)
is a popular hole transport layer (HTL) in 2D Ruddlesden–Popper
(RP) perovskite solar cell (PSCs) due to its highly conductive, transparent,
and solution-processable characteristics. However, fundamental questions
such as its strong acidity or mismatched energy level with the 2D
RP photoactive layer often restrict the performance and stability
of devices. Herein, copper chloride (CuCl), a common direct band gap
semiconductor, is doped into PEDOT:PSS, lowering the acidity and tuning
the work function of PEDOT:PSS. Due to the improved wettability and
the existing chloride in the PEDOT:PSS/CuCl composite substrate, the
coated 2D perovskite films exhibit uniform morphology, vertically
oriented crystal growth, and enhanced crystallinity. In comparison
with controlled devices, the PEDOT:PSS/CuCl based inverted 2D RP PSCs
show a maximum power conversion efficiency of 13.36% and long-term
stability. The modified PEDOT:PSS overcomes intrinsic imperfections
by doping CuCl, indicating that it has a lot of promise for mass production
in electrical devices.
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