A 3D integrated bifunctional electrode of NiCo2O4@NiCoFe–OH nanoarrays is demonstrated for highly efficient oxygen evolution and flexible solid-state zinc–air batteries.

Previous studies have revealed the significance of circulating microRNAs as biomarkers for cancers. The aim of this study was to detect the levels of circulating microRNA-222 (miR-222) in plasma of gastric cancer (GC) patients and evaluate its diagnostic and prognostic value. Levels of circulating miR-222 were detected by using qRT-PCR in plasma of 114 GC patients, 36 chronic atrophic gastritis (CAG) patients and 56 healthy controls. The result showed that the expression of circulating miR-222 in plasma was significantly upregulated in GC compared with CAG and healthy controls (all at P < 0.001). And its high level was significantly correlated with clinical stages (P < 0.001) and lymph nodes metastasis (P = 0.009). The receiver operating characteristics (ROC) curve analyses revealed that miR-222 had considerable diagnostic accuracy, yielded an AUC (the areas under the ROC curve) of 0.850 with 66.1 % sensitivity and 88.3 % specificity in discriminating GC from healthy controls. Moreover, Kaplan-Meier analysis demonstrated a correlation between increased circulating miR-222 level and reduced disease-free survival (P = 0.016) and overall survival (P = 0.012). In multivariate analysis stratified for known prognostic variables, circulating miR-222 was identified as an independent prognostic marker. In conclusion, our findings suggested that circulating miR-222 in plasma might be a potential and useful noninvasive biomarker for the early detection and prognosis of GC.

The global market of flexible/printed and organic electronics is about 41 billion dollars in 2020, which is expected to reach over 74 billion dollars in 2030 according to the relevant reports by IDTechEx. [3] As for the development and expansion toward practical application, flexible/wearable electronics urgently request for flexible energy sources and power devices with high specific energy density and long lifetime. During the past decade, a variety of flexible energy harvesting/conversion (e.g., solar cells, nanogenerators) and energy storage devices (e.g., batteries, supercapacitors, hybrid batteries) have dedicatedly progressed and gained ongoing recognition for future wearable applications. [4][5][6] Among those promising renewable energy technologies, rechargeable lithium-ion batteries (LIBs) have received widespread adoptions for power supplies ranging from mobile/portable electronics to plug-in/ hybrid electric vehicles because of their high working voltage, appreciable energy density, easy use, and ecofriendliness. [7] Flexible LIBs became one of the potential options for powering flexible electronics. With further advance, flexible LIBs are plagued by their limited energy density, deficient safety, and relatively high cost of electrode materials (e.g., lithium, cobalt). In this case, alternative battery technologies, especially metal-air batteries gain immense attention (Table 1). [8,9] Metal-air batteries (MABs) own 2-10 times higher specific energy than current LIBs (200-250 Wh kg −1 ) due to the direct utilization of oxygen from the atmosphere within a halfopen device system. Alongside, rechargeable MABs have more freedom in metallic anodes such as lithium, sodium, potassium, zinc, aluminum and magnesium, etc., where the latter three-based MABs are compatible with aqueous alkaline electrolytes and also intrigued numerous interest. [10][11][12] Given the high theoretical specific energy (1218 Wh kg −1 , 6136 Wh L −1 ), low fabrication cost, high operational safety and environmental benignancy, aqueous zinc-air batteries (ZABs) show far more practical prospect for new-generation energy storage sources. [11] Figure 1 illustrates the brief chronology of the development of ZABs. Dating back to 1878, the first The strong propulsion stem from flexible/wearable electronics has greatly stimulated the development of miniaturized and high-performance rechargeable batteries with adaptable shape. Flexible zinc-air batteries (FZABs), which exhibit high theoretical energy density (1218 Wh kg −1 ), low cost, environmental benignancy, and admirable operational safety, have been widely recognized as one of the promising portable powers to serve future wearable electronics for ubiquitous application. During the past five years, the energy/ power density and cycling stability of FZABs have gained significant improvement largely due to the rational construction of high-efficiency bifunctional air electrodes. Herein, the recent progress of integrated binder-free bifunctional oxygen electrodes is overviewed via elaborate ...

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