Arg-Gly-Asp
(RGD), a classical polypeptide, has been widely used
in cell specific recognition. RGDY (Arg-Gly-Asp-Tyr) consists of the
RGD sequence and tyrosine. Herein, a functional coating with cell-specific
adhesion (with human umbilical vein endothelial cells as the model)
and antiprotein adhesion (with bovine serum albumin as the model)
properties was green synthesized by electrochemical copolymerization
of RGDY and 4-(2-(2-ethoxyethoxy) ethoxy) phenol. Fourier transform
infrared spectroscopy and scanning electron microscopy were used to
characterize the functional groups and morphology of the copolymer,
respectively. Cyclic voltammetry and electrochemical impedance spectroscopy
were used to study the electrochemical performance of the modified
electrode. A quartz crystal microbalance was used to reflect the modification
and antiprotein adhesion process of the copolymer and the following
process of cell-specific adhesion. The cell adsorption and antiprotein
adhesion properties of the modified electrode are significantly improved.
Herein, a green method was used to prepare a stable coating with cell-specific
adhesion and antiprotein adhesion by electrochemical copolymerization
of typical cell-specific recognition peptides and oligopoly(ethylene
glycol) derivatives. It has a potential application value in the modification
of biomaterials, the preparation of cell-specific sensors, and the
development of special biological carriers.
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