The first synthesis of N-substituted lactams via an acceptorless dehydrogenative coupling of diols with primary amines in one step was enabled by combining Ru3(CO)12 with a hybrid N-heterocyclic carbene–phosphine–phosphine ligand as the catalyst.
Unsymmetric Ru-CNP and Ru-CN(H)P complexes are synthesized and applied in hydrogenation of CO2 to formate for the first time. Ru-CNP complex shows excellent stability and high activity. The TON is...
A three-component reaction of β,γ-unsaturated α-keto esters, proline, and dialkyl maleates has been developed. This reaction provides pyrrolizidine derivatives containing three ester groups and a styrenyl group, as well as a quaternary center, in moderate to good yields and with good to excellent diastereoselectivities.
The acceptorless dehydrogenative
cross-coupling of primary alcohols
to form cross-esters with the liberation of H2 gas was
enabled using a [RuCl(η6-C6H6)(κ2-CNP)][PF6]Cl complex as the catalyst.
This sustainable protocol is applicable to a broad range of primary
alcohols, particularly for the sterically demanding ones, featuring
good functional group tolerance and high selectivity. The good catalytic
performance can be attributed to the nitrogen–phosphine-functionalized
N-heterocyclic carbene (CNP) ligand, which adopts a facial coordination
mode as well as the facile dissociation of coordinated benzene.
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