Although many enterprises have been launching the supply-chain finance (SCF) to help firms solve financing problems and increase collaborative performance, the formation process remains limited. The "digital business ecosystem (DBE)" is a sound guiding theory that we adopt to study the process of SCF networks formation, while SCF offers a suitable phenomenon to research how to integrate the business ecosystems and digital platforms to shape DBE and its logic of value. Guided by this lens, we conduct an in-depth case study of a super-large infrastructure enterprise in China. This study reveals a process model which consists of focal IT/IS enablers, dominant types of ecosystems, and forms of ecosystems. Our findings contribute to existing body of literature, in the field of SCF and DBEs. Core firms of ecosystems can use the model to design and develop DBEs to co-create value in SCF with rational deliberation and planning.
Pseudorabies virus (PRV) infections have caused huge economic losses to the breeding industry worldwide, especially pig husbandry. PRV could threaten human health as an easily ignored zoonotic pathogen. The emergence of new mutants significantly reduced the protective effect of vaccination, indicating an urgent need to develop specific therapeutic drugs for PRV infection. In this study, we found that dihydromyricetin (DMY) could dose-dependently restrain PRV infection in vitro with an IC50 of 161.34 μM; the inhibition rate of DMY at a concentration of 500 μM was 92.16 %. Moreover, the mode of action showed that DMY directly inactivated PRV virion and inhibited viral adsorption and cellular replication. DMY treatment could improve PRV-induced abnormal changes of the NF-κB signaling pathway and excessive inflammatory response through regulation of the contents of IκBα and p-P65/P65 and the transcriptional levels of cytokines (TNF-α, IL-1β and IL-6). Furthermore, DMY promoted the apoptosis of PRV-infected cells through the regulation of the expressions of Bax and Bcl-xl and the transcriptional levels of Caspase-3, Bax, Bcl-2 and Bcl-xl, thereby limiting the production of progeny virus. These findings indicated that DMY could be a candidate drug for the treatment of PRV infection.
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