Hydrophobic anticancer drug 5-fluorouracil (5-FU) has been included in the carboxymethyl modified β-cyclodextrin (CMCD), and the inclusion complex (5-FU/CMCD) was further intercalated into galleries of a zinc aluminum layered double hydroxide (ZnAl−LDH) by the ion-exchange method. Powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR), and UV−vis spectroscopy indicate a successful intercalation of 5-FU/CMCD into the LDH gallery. The release behavior of 5-FU from drug/CMCD−LDH composite at different pH values was studied. It was found that 5-FU was released faster in pH 7.2 than in the acidic mediums (pH 4.8), and the released amount was higher. The introduction of CMCD into the LDH matrix could prolong the drug release time in comparison to that from LDH without CMCD, which can be attributed to the inclusion of 5-FU by the CMCD cavity. Studies on mathematical modeling of drug release show that the release of 5-FU from the drug/CMCD−LDH composite follows the Korsmeyer−Peppas equation very well at different pH values. The drug/CMCD inclusion complex intercalated LDH composite in this work provides a supramolecular formulation for controlled release behavior, which can be potentially applied for nonionic and hydrophobic drugs.

A film of carboxymethyl-b-cyclodextrin-intercalated Zn-Al layered double hydroxide (CMCD-LDH) was investigated for selective adsorption of the nucleosides adenosine (A) and guanosine (G). The effects of pH value and adsorption time on the adsorption behavior were studied. The CMCD-LDH film shows a higher selectivity for G than A under identical conditions of G and A, which results from the ability of selective recognition of the interlayer CMCD. The kinetic studies show that adsorption of A and G by the CMCD-LDH film can be described satisfactorily by the slab diffusion model. Both the values of diffusion coefficient (D) and adsorption capability (q e ) of G by the CMCD-LDH film are larger than those of A, demonstrating the selective adsorption of the CMCD-LDH film for nucleosides. Due to its easy preparation and manipulation, this film is expected to be successfully applied in the field of selective adsorption and separation.