Background: Primary lung acinic cell carcinoma is very rare.Here we report a young female patient who suffered the largest primary lung acinic cell carcinoma and severe mediastinal deviation at the same time which has never been reported before.Case presentation: A 27-years-old married female patient presented with recurrent coughing and hemoptysis for more than ten years came to our hospital.A chest computed tomography was performed in our hospital and showed a giant space-occupying lesion in the hilum of right lung.After a thorough and detailed preoperative examination,the patient then was performed a radical right pneumonectomy and mediastinal lymph node dissection.The specimens and pathology showed that the size of the tumor was about 8.6×4.5×4.4cm.The morphology of the tumor cell under microscope demonstrate a primary acinic cell carcinoma of right lung.The immunohistochemistry of the tumor showed AE1/AE3(+), Ki-67(2% +), CK7(+), Calponin(+/-), Vimentin(+), CK19(+), a-ACT(+), PAS(partial+). The patient was discharged two weeks after the operation.So far,the patient has been followed-up for one year, all the clinical test indexes are normal and no evidence of tumor recurrence or metastasis was observed. Conclusions: The primary acinic cell carcinoma of lung in this case is the biggest one ever been reported.The patient also had a very rare condition of severe mediastinal deviation.After surgical treatment, the patient recovered uneventfully and had stable disease without recurrence after one year of follow-up.This case indicates that acinic cell carcinoma of lung is of low malignancy, the prognosis and therapy effect of surgical treatment are satisfied.
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