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Water availability in the dry western United States (US) under climate change and increasing water use demand has become a serious concern. Previous studies have projected future runoff changes across the western US but ignored the impacts of ecosystem response to elevated CO2 concentration. Here, we aim to understand the impacts of elevated CO2 on future runoff changes through ecosystem responses to both rising CO2 and associated warming using the Noah‐MP model with representations of vegetation dynamics and plant hydraulics. We first validated Noah‐MP against observed runoff, leaf area index (LAI), and terrestrial water storage anomaly from 1980 to 2015. We then projected future runoff with Noah‐MP under downscaled climates from three climate models under Representative Concentration Pathway 8.5. The projected runoff declines variably from the Pacific Northwest by −11% to the Lower Colorado River basin by −92% from 2016 to 2099. To discern the exact causes, we conducted an attribution analysis of the modeled evapotranspiration from two additional sensitivity experiments: one with constant CO2 and another one with static monthly LAI climatology. Results show that surface “greening” (due to the CO2 fertilization effect) and the stomatal closure effect are the second largest contributors to future runoff change, following the warming effect. These two counteracting CO2 effects are roughly compensatory, leaving the warming effect to remain the dominant contributor to the projected runoff declines at large river basin scales. This study suggests that both surface “greening” and stomatal closure effects are important factors and should be considered together in water resource projections.

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Stem cells possess regenerative powers and multidirectional differentiation potential and play an important role in disease treatment and basic medical research. Urine-derived stem cells (USCs) represent a newly discovered type of stem cell with biological characteristics similar to those of mesenchymal stromal cells (MSCs), including their doubling time and immunophenotype. USCs are noninvasive and can be readily obtained from voided urine and steadily cultured. Based on advances in this field, USCs and their secretions have increasingly emerged as ideal sources. USCs may play regulatory roles in the cellular immune system, oxidative stress, revascularization, apoptosis and autophagy. This review summarizes the applications of USCs in tissue regeneration and various disease treatments. Furthermore, by analysing their limitations, we anticipate the development of more feasible therapeutic strategies to promote USC-based individualized treatment.