The popularization of biobanks provides an unprecedented amount of genetic and phenotypic information that can be used to research the relationship between genetics and human health. Despite the opportunities these datasets provide, they also pose many problems associated with computational time and costs, data size and transfer, and privacy and security. The publishing of summary statistics from these biobanks, and the use of them in a variety of downstream statistical analyses, alleviates many of these logistical problems. However, major questions remain about how to use summary statistics in all but the simplest downstream applications. Here, we present a novel approach to utilize basic summary statistics (estimates from single marker regressions on single phenotypes) to evaluate more complex phenotypes using multivariate methods. In particular, we present a covariate-adjusted method for conducting principal component analysis (PCA) utilizing only biobank summary statistics. We validate exact formulas for this method, as well as provide a framework of estimation when specific summary statistics are not available, through simulation. We apply our method to a real data set of fatty acid and genomic data.
Crashes among young and inexperienced drives are a major safety problem in the United States, especially in an area with large rural road networks, such as West Texas. Rural roads present many unique safety concerns that are not fully explored. This study presents a complete machine leaning pipeline to find the patterns of crashes involved with teen drivers no older than 20 on rural roads in West Texas, identify factors that affect injury levels, and build four machine learning predictive models on crash severity. The analysis indicates that the major causes of teen driver crashes in West Texas are teen drivers who failed to control speed or travel at an unsafe speed when they merged from rural roads to highways or approached intersections. They also failed to yield on the undivided roads with four or more lanes, leading to serious injuries. Road class, speed limit, and the first harmful event are the top three factors affecting crash severity. The predictive machine learning model, based on Label Encoder and XGBoost, seems the best option when considering both accuracy and computational cost. The results of this work should be useful to improve rural teen driver traffic safety in West Texas and other rural areas with similar issues.
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