This study proposed a GAN-based reconstruction method-cascaded data consistency generative adversarial network (CDCGAN) to recover high-quality PET images from filtered back projection PET images with streaking artifacts and high noise. First, the authors embed defined data consistency layer (DC layer) in their generator network to constrain the reconstruction process and adjust accurately generated faked PET images. Second, to improve the accuracy of reconstruction on average, their generator network was built iteratively to achieve better performance with simple structures. They observed that the proposed CDCGAN allows the preservation of fine anomalous features while eliminating the streaking artifacts and noise. Experimental results show that the reconstructed PET images by their methods perform well comparably to other state-of-the-art methods but at a faster speed. A clinical experiment was also performed to show the validity of the CDCGAN for artifacts reduction.
Aiming at the problems of long time, high cost, invasive sampling damage, and easy emergence of drug resistance in lung cancer gene detection, a reliable and non-invasive prognostic method is proposed. Under the guidance of weakly supervised learning, deep metric learning and graph clustering methods are used to learn higher-level abstract features in CT imaging features. The unlabeled data is dynamically updated through the k-nearest label update strategy, and the unlabeled data is transformed into weak label data and continue to update the process of strong label data to optimize the clustering results and establish a classification model for predicting new subtypes of lung cancer imaging. Five imaging subtypes are confirmed on the lung cancer dataset containing CT, clinical and genetic information downloaded from the TCIA lung cancer database. The successful establishment of the new model has a significant accuracy rate for subtype classification (ACC = 0.9793), and the use of CT sequence images, gene expression, DNA methylation and gene mutation data from the cooperative hospital in Shanxi Province proves the biomedical value of this method. The proposed method also can comprehensively evaluate intratumoral heterogeneity based on the correlation between the final lung CT imaging features and specific molecular subtypes.
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