Surfactant-like peptides (SLPs) can self-assemble into various nanostructures, which have shown great potential for a variety of biomedical and biotechnological applications. In this work, two SLPs, V 4 Y, and V 4 AGY, were designed and synthesized, both of which had hydrophobic head valines (V) with large side-chain steric hindrance effect and the hydrophilic head tyrosine (Y) with a rigid ring and two negative charges in the basic solution. Fourier transform infrared and circular dichroism studies confirmed their different secondary structures, whereas atomic force microscopy and dynamic light scattering characterized the difference in their morphologies. In solution, they formed different secondary structures. Correspondingly, V 4 Y and V 4 AGY formed noncompact spherical aggregates and a spiral clubbed structure, respectively. In V 4 AGY, the introduction of alanine (A) and glycine (G) increased the molecule's flexibility and increased the distance between the tyrosine and four continuous valines, so as to weaken the synergistic action of electronic repulsion and steric hindrance and strengthen the intermolecular hydrogen bond beneficial to β-sheet formation and the axial growth of the self-assembly. Therefore, the flexibility of the molecule and the side-chain steric effect of the two heads of SLPs are non-negligible in the tuning process of peptide self-assembly, in addition to hydrogen-bonding, hydrophobic, and electrostatic interactions.
The aim of this work is to determine the theta temperatures
of
chlorinated poly(propene) solutions. The cloud point temperatures
of chlorinated poly(propene) in ethyl acetate, butanone, and 1,4-dioxane
solutions were determined at various concentrations. The theta temperatures
of chlorinated poly(propene) solutions were determined by the linearity
of the reciprocal cloud point temperature against the logarithm of
the polymer volume fraction. The theta temperatures of chlorinated
poly(propene) in ethyl acetate, butanone, and 1,4-dioxane solutions
are 353.11 K, 347.95 K, and 335.91 K, respectively. The theta temperature
increases with the decrease of solubility. The lower the solubility
of chlorinated poly(propene) in solvent, the larger is the free energy
of mixing, the weaker is the spontaneous dissolution, and the higher
is the theta temperature.
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