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By 3D particle-in-cell simulation and analysis, we propose a plasma lens to make high intensity, high contrast laser pulses with a steep front. When an intense, short Gaussian laser pulse of circular polarization propagates in near-critical plasma, it drives strong currents of relativistic electrons which magnetize the plasma. Three pulse shaping effects are synchronously observed when the laser passes through the plasma lens. The laser intensity is increased by more than 1 order of magnitude while the initial Gaussian profile undergoes self-modulation longitudinally and develops a steep front. Meanwhile, a nonrelativistic prepulse can be absorbed by the overcritical plasma lens, which can improve the laser contrast without affecting laser shaping of the main pulse. If the plasma skin length is properly chosen and kept fixed, the plasma lens can be used for varied laser intensity above 10(19) W/cm(2).

Ion acceleration by circularly polarized laser pulses interacting with foil targets is studied using two dimensional particle-in-cell simulations. It is shown that laser pulses with transverse super-Gaussian profile help in avoiding target deformation as compared with the usual Gaussian pulse. This improves monochromaticity of the accelerated ion spectrum. Two kinds of surface instabilities have been found during the interaction. These instabilities can potentially break the target and destroy the quasimonoenergetic character of the final ion spectrum. Combined laser pulses with super-Hermite and Gaussian modes are used to improve the ion acceleration and transverse collimation.

Ion beam therapy for cancer has proven to be a successful clinical approach, affording as good a cure as surgery and a higher quality of life. However, the ion beam therapy installation is large and expensive, limiting its availability for public benefit. One of the hurdles is to make the accelerator more compact on the basis of conventional technology. Laser acceleration of ions represents a rapidly developing young field. The prevailing acceleration mechanism (known as target normal sheath acceleration, TNSA), however, shows severe limitations in some key elements. We now witness that a new regime of coherent acceleration of ions by laser (CAIL) has been studied to overcome many of these problems and accelerate protons and carbon ions to high energies with higher efficiencies. Emerging scaling laws indicate possible realization of an ion therapy facility with compact, cost-efficient lasers. Furthermore, dense particle bunches may allow the use of much higher collective fields, reducing the size of beam transport and dump systems. Though ultimate realization of a laser-driven medical facility may take many years, the field is developing fast with many conceptual innovations and technical progress.