Highlights d Cryo-EM structure of NPC1 embedded in nanodiscs was determined at 3.6 Å resolution d Distinct conformations of NPC1-SSD at pH 5.5 and 8.0 suggest pH dependency d Two states of NPC1-NTD and a sterol-bearing central tunnel were resolved at pH 5.5 d The cryo-EM structure of full-length NPC2/ NPC1 complex was determined at 4.
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