Flexible
luminescent materials, with the advantages of foldability and crack
resistance, have attracted extensive interest owing to their broad
application in collapsible optoelectronic devices. In this work, highly
luminescent and flexible films were fabricated via self-assembly of
triple building blocks: layered double hydroxide (LDH) nanoplatelets,
polyvinyl alcohol (PVA), and quantum dots (QDs: CdTe or CdSe/ZnS),
which show 2D ordered structure and finely tunable fluorescence (green,
yellow, orange, and red). The resulting films display rather strong
fluorescence and high fluorescence quantum yield (PLQY), which can
be attributed to the uniform dispersion of QDs within the inorganic–organic
hybrid matrix. Furthermore, we incorporated the red-emitting LDH/(PVA-CdSe/ZnS)
film with the commercialized white light-emitting diodes (WLED) and
obtained significantly improved color-rendering property through modifying
its spectral distribution. In addition, the LDH/PVA-QDs films display
high photo- and thermostability. Therefore, this work provides a facile
approach for the design and fabrication of clay–polymer–QDs
hybrid luminescent films with exceptional light emission, flexibility,
and stability, which can serve as promising materials for the integration
of WLED illumination devices.
Salt-inducible kinase 2 (SIK2; also known as serine/threonine-protein kinase SIK2) is overexpressed in several cancers and has been implicated in cancer progression. However, the mechanisms by which SIK2 regulates cancer cell motility, migration and metastasis in ovarian cancer have not been fully discovered. Here, we identify that SIK2 promotes ovarian cancer cell motility, migration and metastasis in vitro and in vivo. Mechanistically, SIK2 regulated cancer cell motility and migration by myosin light chain kinase, smooth muscle (MYLK)-meditated phosphorylation of myosin light chain 2 (MYL2). SIK2 directly phosphorylated MYLK at Ser343 and activated its downstream effector MYL2, promoting ovarian cancer cell motility and metastasis. In addition, we found that adipocytes induced SIK2 phosphorylation at Ser358 and MYLK phosphorylation at Ser343, enhancing ovarian cancer cell motility. Moreover, SIK2 protein expression was positively correlated with the expression of MYLK-pS343 in ovarian cancer cell lines and tissues. The coexpression of SIK2 and MYLK-pS343 was associated with reduced median overall survival in human ovarian cancer samples. Taken together, SIK2 positively regulates ovarian cancer motility, migration and metastasis, suggesting that SIK2 is a potential candidate for ovarian cancer treatment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.