Background:The relationship between vitamin intake and pancreatic cancer (PC) risk is disputed. We aimed to investigate the association between vitamin intake and the risk of PC via meta-analysis.Methods:We conducted a meta-analysis of studies concerning vitamin intake and the risk of PC from EMBASE, MEDLINE, and Cochrane Library. The search yielded 25 correlative studies including 1,214,995 individuals. The relative risks (RR) were examined by a random-effect model or fixed-effect model. Subgroup analysis, dose–response analysis, sensitivity analysis, meta-regression, and publication bias analysis were used to analyze studies.Results:The RR of PC in the highest vitamin intake group was 0.90 (95% confidence interval, 0.83–0.98) compared with that in the lowest vitamin intake in the prospective studies. Different increments of vitamin intake and the risk of PC were examined with dose–response analysis, and a decrease in the risk of PC was observed with vitamin D (25%) and vitamin B12 (27%).Conclusions:This meta-analysis found that vitamin intake can decrease the risk of PC, particularly vitamin D and vitamin B12.
Background: The prognosis of lung cancer is related to the stage of the disease at the time of detection, and early diagnosis can prolong survival time. In this prospective observational cohort research, we aimed to analyze the diagnostic performance of the combined application of ACSL4 and low-dose 256-slice spiral computed tomography (CT) to lung cancer. Methods: This prospective observational cohort research enrolled a total of 512 patients with pulmonary nodules (PN) who were found with PN by CT. All patients were divided into 2 groups through biopsy operation, including 449 patients with benign PN and 63 patients with malignant PN. Both groups were scanned with a Philips Brilliance 256iCT machine. Imaging features of PN were recorded. All images of the nodules were used for data measurement and image analysis by the Lung Nodule Assessment analysis software. The serum ACSL4, carcinoembryonic antigen (CEA), cytokeratin 19 fragment 21-1 (CYFRA21-1), neuron-specific enolase, carbohydrate antigen 199 (CA199) and carbohydrate antigen 125 (CA125) levels were measured by enzyme-linked immunosorbent assay method. The demographic data and clinical data, including age, sex, body mass index, smoke condition, TNM stage, lymph node metastasis and distant metastasis were collected. All the patients were followed for 5 years. Statistical analysis was conducted using SPSS software with P < .05 as statistically different. Results: The diameter of nodules, the proportion of burr signs and smoking status, and the serum levels of CEA, CYFRA21-1, CA199, CA125 were significantly higher in malignant nodules group compared with the benign nodules group. Serum ACSL4 levels of malignant nodules group (19.33 ± 6.92 ng/mL) were remarkably lower than the benign nodules group (25.34 ± 3.78 ng/mL). ACSL4 was negatively correlated with CEA, CYFRA21-1, CA199, and CA125. ACSL4 was associated with the clinical outcomes in malignant PN patients and lower ACSL4 predicted poor clinic outcomes and prognosis. In addition, ACSL4 combined with low-dose 256-slice spiral CT had satisfactory diagnostic value for lung cancer. Conclusion: In summary, our results showed that combination application of ACSL4 and low-dose 256-slice spiral CT might be a potential method for the early screening of lung cancer.
Are land-expropriated, urbanised residents living happily? This question is not only related to the quality of urbanisation but also has important reference for evaluating the reform of the land acquisition system. On the basis of the Chinese General Social Survey data in 2017 and 2018, the HeckProbit model, the ordered probit model and the mediating effect model were used to study the happiness and underlying mechanism of land-expropriated, urbanised residents. The results showed that the older the farmers are, the lower the probability of obtaining urban hukou through land acquisition, and women will be more likely to achieve household registration through land requisition. Education and party status have significant inhibitory effects on hukou conversion through land acquisition. A comparison among multiple groups indicated that the happiness level of each group is ranked as follows: residents who attained urban hukou through education and job recruitment > urban native residents > land-expropriated, urbanised residents > farmers; however, the happiness level of the latter two groups has no significant difference. The propensity score matching method was further used to reduce the endogeneity due to selection bias, and the results were still robust. The lower self-assessment of socioeconomic status indirectly caused the loss of happiness of land-expropriated, urbanised residents. However, the high living expectation ‘suppressed’ the negative effect of land acquisition on happiness to some extent.
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