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Camellia oleifera (Camellia oleifera Abel.), which belongs to Theaceae, is an endemic woody edible oil tree species in China, and it is also one of the four major woody oil crops in the world (Liang et al., 2017). Camellia seed oil (CSO) is a vegetable oil extracted from camellia seeds, which fatty acid composition and physical and chemical properties are very similar to olive oil, so it is known as "Oriental Olive Oil" (Zhu et al., 2020). It is rich in monounsaturated fatty acids and a variety of functional active ingredients, such as squalene, phytosterols (β-sitosterol, rapeseed sterol, and stigmasterol), polyphenols, fat-soluble vitamins (vitamins A, B, E), and so on, which has high nutritional value and health-care function (Shi et al., 2020). Therefore, long-term consumption of CSO can prevent cardiovascular sclerosis, lower cholesterol, anti-oxidation, pro

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In this study, Camellia nitidissima Chi leaf extract was investigated for its compounds and pancreatic lipase inhibitory potentials. The interaction was determined using ultraviolet (UV) spectroscopy, circular dichroism (CD), fluorescence spectroscopy (FS), and molecular docking to understand the inhibiton, kinetic, and conformation of extraction–pancreatic lipase complex. C. nitidissima Chi leaf extraction inhibited the pancreatic lipase activity in a dose‐dependent manner at the concentration of 1–12 mg/ml. The Lineweaver–Burk plots indicated that the inhibition on pancreatic lipase by extraction was noncompetitive. In addition, the decrease in α‐helix contents, increase in β‐sheet and β‐turn, and decrease in fluorescence intensity after extraction treatment indicated that the conformation of pancreatic lipase was changed. This work revealed that C. nitidissima Chi leaf extraction played a significant role in inhibiting pancreatic lipase activity and brought out a solution of delay fat accumulation. Practical applications This study reports the components in the extract of C. nitidissima Chi leaf and its inhibitory effect and mechanism of pancreatic lipase. C. nitidissima Chi leaf is a good source of bioactive components, including multiflorin B, kaempferol‐3‐O‐rutinoside, vicenin‐2, apigenin‐6‐C‐pentosyl‐8‐C‐hexosyl, vitexin, kaempferol, and other ingredients. It can inhibit pancreatic lipase and be used to control obesity and treat hyperlipidemia. This study also revealed the structure changes of C. nitidissima Chi leaf extract on pancreatic lipase, and further revealed the inhibitory mechanism of C. nitidissima Chi leaf extract on lipase, which provides a theoretical basis for C. nitidissima Chi leaf as a lipase inhibitor.

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