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In vascular tissue engineering, a scaffold that can enhance the proliferation of endothelial cells (ECs) while inhibiting the synthetic differentiation of smooth muscle cells (SMCs) is crucial to prevent thrombus and restenosis after graft implantation. However, it is always challenging to incorporate both properties simultaneously in a vascular tissue engineering scaffold. In this study, a novel composite material was developed by combining a synthetic biopolymer of poly(l-lactide-co-caprolactone) (PLCL) and a natural biopolymer of elastin through electrospinning. Cross-linking of the PLCL/elastin composite fibers using EDC/NHS was performed to stabilize the elastin component. The incorporation of elastin into PLCL was found to enhance the hydrophilicity and biocompatibility of the resulting PLCL/elastin composite fibers, as well as the mechanical properties. Additionally, as a natural component of the extracellular matrix, elastin displayed antithrombotic properties reducing platelet adhesion and improving blood compatibility. Results of cell culture experiments with human umbilical vein ECs (HUVECs) and human umbilical artery SMCs (HUASMCs) showed that the composite fiber membrane had high cell viability, promoting the proliferation and adhesion of HUVECs and inducing a contractile phenotype in HUASMCs. These results indicate that the PLCL/elastin composite material has great potential for use in vascular graft applications due to its favorable properties and rapid endothelialization and contractile phenotypes of cells.

Preferential flow is a non-equilibrium flow in unsaturated soil through which water infiltrates deep into the ground quickly. It has been studied in many fields, such as environment, agriculture, and hydrology. However, researchers from different disciplines have a different understanding of preferential flow, and it is difficult to grasp its development trends and research frontiers through qualitative analysis in a single field, while they can be quantitatively and objectively analyzed through bibliometrics with scientific knowledge map tools. This paper collects 3315 research studies on preferential flow in soil from the Web of Science (WoS) core collection database within 30 years, conducts a statistical analysis on keywords, countries, and research institutions of these studies based on CiteSpace, draws visualized scientific knowledge maps, and presents the development trends and research frontiers of preferential flow. Results showed that preferential flow is a multi-scale coexistence phenomenon, and researchers from different disciplines study preferential water flow movement and pollution at different research scales. New techniques and ideas are research hotspots and directions. Moreover, the difference between bibliometrics methods and review methods is analyzed. This paper is presented to provide a referable knowledge structure and new ideas for research in related fields and to help promote cross-integration between disciplines.

Central airway stenosis is a condition that the diameter of the trachea or main bronchus shrinkage is caused by external compression or internal tissue hyperplasia, which can cause difficulty breathing, asphyxia, and even death. Airway stenting is an easy way to restore the patency of the central airway, but airway stents commonly used in clinical practice can lead to complications such as mucus plugging, bacterial infection, and granulation tissue hyperplasia. Moreover, the non‐degradable characteristic makes it requires a second operation to remove, which has the potential to cause tissue damage. In this study, a biodegradable airway stent is fabricated by microinjection molding using the bioelastomer of poly (L‐lactide‐co‐ε‐caprolactone) as the matrix material. The airway stent has excellent mechanical properties and an appropriate degradation rate. The hydrophilic surface of the airway stent can inhibit mucus plugging. The loading of silver nanoparticles and cisplatin endows the stent with antibacterial and anti‐hyperplastic functions. In vitro and in vivo experiments demonstrate that this study provides an antibacterial and anti‐hyperplastic biodegradable airway stent with elastic properties to avoid secondary removal operation and reduce complications associated with mucus plugging, bacterial infection, and granulation tissue hyperplasia.