Natural skin–derived products, as traditional wearable materials are widely used in people's daily life due to the products’ excellent origins. Herein, a versatile daytime‐radiation cooling wearable natural skin (RC‐skin) consisting of the collagen micro‐nano fibers with the on‐demand double‐layer radiation cooling structure is nano‐engineered through the proposed facile “synergistic inner–outer activation” strategy. The bottom layer (inner strategy) of the RC‐skin is fabricated by filling the skin with the Mg11(HPO3)8(OH)6 nanoparticles by soaking. The superstratum (outer strategy) is constituted by a composite coating with an irregular microporous structure. The RC‐skin harvests the inherent advantages of natural building blocks including sufficient hydrophobicity, excellent mechanical properties, and friction resistance. Owing to the subtle double‐layer structure design, the solar reflectance and the average emissivity in the mid‐infrared band of RC‐skin are ≈92.7% and ≈95%, respectively. Therefore, the RC‐skin's temperature in the sub‐ambient is reduced by ≈7.5 °C. Various outdoor practical application experiments further substantiate that RC‐skin has superior radiation cooling performances. Collectively, RC‐skin has broad‐application prospects for intelligent wearing, low‐carbon travel, building materials, and intelligent thermoelectric power generation, and this study also provides novel strategies for developing natural‐skin–derived functional materials.
Formaldehyde
(FA) is a typical volatile organic compound widely
used in diverse fields, including decoration materials, textiles,
and chemical processing. However, FA is also a carcinogen and poses
a serious threat to human health. Therefore, the development of a
rapid and efficient method for the detection of FA is a pressing concern.
Herein, a kind of self-assembled fluorescent nanoparticle (CS-OCH3@NBHN) was designed and constructed by using a chitosan-based
fluorescent probe (CS-OCH3
) as a carrier,
which was loaded with a small-molecule FA fluorescent probe. The nanoprobe CS-OCH3@NBHN proved to be rapid and highly sensitive
for FA recognition, with a ratiometric fluorescence response of less
than 10 min and a detection limit of 66.29 nM. In addition, the probe
exhibited high selectivity to FA, good anti-interference ability,
and a wide pH application range (pH 3.0–11.0). More importantly,
it is applied for the sensitive detection of FA in aqueous solution,
air, leather samples, and living cells.
Developing selective inhibitors for Janus kinase 1 (JAK1)
is a
significant focus for improving the efficacy and alleviating the adverse
effects in treating immune–inflammatory diseases. Herein, we
report the discovery of a series of C-5 pyrazole-modified pyrrolopyrimidine
derivatives as JAK1-selective inhibitors. The potential hydrogen bond
between the pyrazole group and E966 in JAK1 is the key point that
enhances JAK1 selectivity. These compounds exhibit 10- to 20-fold
JAK1 selectivity over JAK2 in enzyme assays. Compound 12b also exhibits excellent JAK1 selectivity in Ba/F3-TEL-JAK cellular
assays. Metabolism studies and the results of the hair growth model
in mice indicate that compound 12b may be a viable lead
compound for the development of highly JAK1-selective inhibitors for
immune and inflammatory diseases.
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