Wearable thermoelectric devices show promises to generate electricity in a ubiquitous, unintermittent and noiseless way for on-body applications. Threedimensional thermoelectric textiles (TETs) outperform other types in smart textiles owing to their out-of-plane thermoelectric generation and good structural conformability with fabrics. Yet, there has been lack of efficient strategies in scalable manufacture of TETs for sustainably powering electronics. Here, we fabricate organic spacer fabric shaped TETs by knitting carbon nanotube yarn based segmented thermoelectric yarn in large scale. Combing finite element analysis with experimental evaluation, we elucidate that the fabric structure significantly influences the power generation. The optimally designed TET with good wearability and stability shows high output power density of 51.5 mW/m 2 and high specific power of 173.3 µW/(g·K) at ∆T= 47.5 K. The promising on-body applications of the TET in directly and continuously powering electronics for healthcare and environmental monitoring is fully demonstrated. This work will broaden the research vision and provide new routines for developing high-performance and large-scale TETs toward practical applications.

The Warburg effect, characterized by increased glucose uptake and lactate production, is a well-known universal across cancer cells and other proliferating cells. PKM2, a splice isoform of the pyruvate kinase (PK) specifically expressed in these cells, serves as a major regulator of this metabolic reprogramming with an adjustable activity subjected to numerous allosteric effectors and posttranslational modifications. Here, we have identified a posttranslational modification on PKM2, GlcNAcylation, which specifically targets Thr and Ser, residues of the region encoded by the alternatively spliced exon 10 in cancer cells. We show that PKM2 GlcNAcylation is up-regulated in various types of human tumor cells and patient tumor tissues. The modification destabilized the active tetrameric PKM2, reduced PK activity, and led to nuclear translocation of PKM2. We also observed that the modification was associated with an increased glucose consumption and lactate production and enhanced level of lipid and DNA synthesis, indicating that GlcNAcylation promotes the Warburg effect. In vivo experiments showed that blocking PKM2GlcNAcylation attenuated tumor growth. Thus, we demonstrate that GlcNAcylation is a regulatory mechanism for PKM2 in cancer cells and serves as a bridge between PKM2 and metabolic reprogramming typical of the Warburg effect.

Wearable inorganic semiconductors (ISCs) based thermoelectric (TE) devices, especially fiber-based thermoelectric textiles (TETs), show promises in electrical power generation and solid-state cooling compared with bulk ISCs-based TE generators (TEGs). However,...

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Ocean wave energy conversion as one of the renewable clean energy sources is attracting the research interests of many people. This review introduces different types of power take-off (PTO) technology of wave energy converters. The novelty of this paper is to present advantages and disadvantages of the linear direct and indirect drive PTO devices for ocean wave energy conversion. The designs and optimizations of PTO systems of ocean wave energy converters have been studied from reviewing the recently published literature. The novel mechanical designs of the PTO systems have been compared and investigated in order to increase the energy harvesting efficiency.

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