Refractory prolonged isolated thrombocytopenia (RPIT) is an intractable complication after allogeneic hematopoietic cell transplantation (HCT), which often leads to poor prognosis. A clinical study was designed to validate the efficacy and safety of low-dose decitabine for RPIT after HCT and explore the related underlying mechanisms. Eligible patients were randomly allocated to receive 1 of 3 interventions: arm A, low-dose decitabine (15 mg/m2 daily IV for 3 consecutive days [days 1-3]) plus recombinant human thrombopoietin (300 U/kg daily); arm B, decitabine alone; or arm C, conventional treatment. The primary end point was the response rate of platelet recovery at day 28 after treatment. Secondary end points included megakaryocyte count 28 days after treatment and survival during additional follow-up of 24 weeks. Among the 91 evaluable patients, response rates were 66.7%, 73.3%, and 19.4% for the 3 arms, respectively (P < .001). One-year survival rates in arms A (64.4% ± 9.1%) and B (73.4% ± 8.8%) were similar (P = .662), and both were superior to that in arm C (41.0% ± 9.8%; P = .025). Megakaryocytes, endothelial cells (ECs), and cytokines relating to megakaryocyte migration and EC damage were improved in patients responding to decitabine. This study showed low-dose decitabine improved platelet recovery as well as overall survival in RPIT patients after transplantation. This trial was registered at www.clinicaltrials.gov as #NCT02487563.
Prestressed concrete (PC) box-girders with corrugated steel webs are one of the promising steel concrete composite structures applied to highway bridges. Although the basic structural characteristics including bending, shearing and torsion, etc., have been paid much attention, few researches on the seismic performance of this type of bridges are found, especially when the span of this type of bridges becomes larger and larger. In this paper, the seismic performance of one long-span PC box-girder bridge with corrugated steel webs is studied and compared with a conventional box-girder bridge with concrete webs, based on response spectrum analysis using ANSYS. The results show that, the vertical and transverse displacements of the box-girder with corrugated steel webs are slightly less than those of the box-girder with concrete webs, but the longitudinal displacement reverses, under the same earthquake excitation. The bending moments of representative sections of the box-girder bridge with corrugated steel webs are only about 70% ~ 90% of those of the corresponding conventional PC girder bridge. The results indicate that the box-girder bridge will have better seismic performance if the corrugated steel webs are adopted instead of the concrete webs, but it could also fulfill the tasks such as displacement control which resulted from stiffness reduction.
This paper presents a numerical strategy to model nonlinear damage behavior of RC members based on level of material. The first part of the paper presents a numerical model of the RC member based on the Timoshenko multifiber beam elements and non-linear damage constitutive laws for concrete, and the effective three dimensional fiber beam-column element model is developed for the nonlinear damage analysis of RC members with VUEL subroutine based on ABAQUS/Explicit platform. In the second part, a nonlinear damage analysis for RC members is established by analyzing the sections of fiber beam column elements, and the member damage index through statistical analysis of concrete fibers damage is defined in the extreme section of beam elements, which can describe the nonlinear damage behavior of RC members under any loadings. Accuracy of the model is identified preliminarily by comparing with the analysis results of solid elements, the results shows that it seems now possible to use this approach to investigate numerically the nonlinear damage behavior of RC members based on level of material.
Three cases for 1-D wave propagation in ideal elastic rock, through single rock joint and multiple parallel rock joints are used to verify 1-D wave propagation in rocks. For the case for 1-D wave propagation through single rock joint, the magnitude of transmission coefficient obtained from UDEC results is compared with that obtained from the analytical solution. For 1-D wave propagation through multiple parallel joints, the magnitude of transmission coefficient obtained from UDEC results is compared with that obtained from the method of characteristics. For all these cases, UDEC results agree well with results from the analytical solutions and the method of characteristics. From these verification studies, it can be concluded that UDEC is capable of modeling 1-D dynamic problems in rocks.
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