The bioactivity-guided isolation on the Scutellaria barbata extract resulted in the purification of four undescribed neo-clerodane diterpenoids, scuttenlines A -D (1 -4), alone with 20 known diterpenoids (5 -24). The chemical structures of them were elaborated by extensive spectroscopic means, including 1D, 2D-NMR and HR-MS. The anti-inflammatory potential ability of 1 -24 was screened in lipopolysaccharide-stimulated mouse RAW 264.7 cells. Scuttenline C (IC 50 = 1.9 μM) and 18 (IC 50 = 3.7 μM) exhibited potent activity to inhibit NO production.
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