No abstract

Our study shows that iron overload injures the hematopoiesis by damaging hematopoietic cell and hematopoietic microenvironment, which is mediated by ROS-related signaling proteins.

Previous studies reported that miR-433 exerts function widely in human tumorigenesis and development. Here, we further investigate the potential role of miR-433 in glioma. Quantitative real-time PCR demonstrated that miR-433-3p and miR-433-5p were low expressed in glioma tissues and cell lines. Functional studies suggested that the overexpression of miR-433-3p suppressed proliferation, induced apoptosis and inhibited invasion and migration of human glioma cells. But the growth and metastasis of glioma cells were not significantly influenced by overexpression of miR-433-5p. In a xenograft model, we also showed that miR-433-3p had an inhibitory effect on the growth of glioma. Bioinformatics coupled with luciferase and western blot assays revealed that CREB is a direct target of miR-433-3p, and the overexpression of CREB can rescue the phenotype changes induced by miR-433-3p overexpression. Besides, miR-433-3p could increase chemosensitivity of glioma to temozolomide by targeting CREB in vitro and in vivo. Taken together, these results suggest that miR-433-3p may function as a potential marker in diagnostic and therapeutic target for glioma.

Abstract. the HiWi gene is one of the members of the PiWi gene family that is important for stem cell self-renewal and expressed highly in certain human tumors. Some studies have demonstrated that HiWi plays a key role in the development of tumors in cervical, colon and liver cancer. Previous studies have demonstrated that HiWi is associated with prognosis of patients with glioma. However, there is no report on the analysis of HiWi in the biological characteristics of glioma cells. the aim of the study was to investigate whether HiWi plays an important role in the progress of glioma. Silencing HiWi inhibited cell proliferation by promoting apoptosis and increased cell cycle arrest. the expression of proteins related to apoptosis and the cell cycle, including p21, cyclin D1, Bcl-2, and Bax was significantly altered. Moreover, knockdown of HiWi inhibited the migration and invasion of glioma cells by reducing the expression of MMP-2 and MMP-9. furthermore, we found that reduction of HiWi inhibited tumor growth in vivo. These findings suggest that HIWI is an oncogene involved in the progression of glioma.

Remaining useful life (RUL) prediction has great importance in prognostics and health management (PHM). Relaxation effect refers to the capacity regeneration phenomenon of lithium-ion batteries during a long rest time, which can lead to a regenerated useful time (RUT). This paper mainly studies the influence of the relaxation effect on the degradation law of lithium-ion batteries, and proposes a novel RUL prediction method based on Wiener processes. This method can simplify the modeling complexity by using the RUT to model the recovery process. First, the life cycle of a lithium-ion battery is divided into the degradation processes that eliminate the relaxation effect and the recovery processes caused by relaxation effect. Next, the degradation model, after eliminating the relaxation effect, is established based on linear Wiener processes, and the model for RUT is established by using normal distribution. Then, the prior parameters estimation method based on maximum likelihood estimation and online updating method under the Bayesian framework are proposed. Finally, the experiments are carried out according to the degradation data of lithium-ion batteries published by NASA. The results show that the method proposed in this paper can effectively improve the accuracy of RUL prediction and has a strong engineering application value.