A Cu-catalyzed
aromatic C–H amidation with phthalimide under
oxygen as a terminal oxidant without using additional additives has
been achieved. This reaction has the broad substrate scope and shows
moderate to good yields in most cases. This method is complementary
to the previously reported metal-catalyzed C–H amination systems.
Cut and paste! A Cu‐catalyzed aromatic CH cyanation with acetonitrile as the nitrile source by CCN cleavage has been developed (see scheme; TMEDA=N,N,N′,N′‐tetramethylethylenediamine). The reaction is catalytic in copper, and it is found that using (Me3Si)2 as an additive plays a critical role in promoting CCN cleavage and enhancing the reaction rate.
The copper‐mediated C‐H chlorination and bromination of 2‐arylpyridines, substituted with both electron‐donating and electron‐withdrawing groups affords the halogenated products in low to moderate yields and poor selectivity.
The copper-catalyzed C-H halogenation of 2-arylpyridines containing a variety of electron-withdrawing and electron-donating substituents was described. It is worth noting that cheap and easy-to-handle lithium halides were utilized as the halogen sources.
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