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Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.

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A Straightforward One-Pot Multicomponent Synthesis of Polysubstituted Pyrroles. -The synthesis of pyrroles (IV) by a multicomponent reaction is elaborated. The hydrolysis of ester (IVf) followed by a palladium-catalyzed decarboxylative, intramolecular coupling leads to benz[g]indole derivative (VII) in high yield. -(LIN*, X.; MAO, Z.; DAI, X.; LU, P.; WANG*, Y.; Chem. Commun. (Cambridge) 47 (2011) 23, 6620-6622, http://dx.

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