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Equatorial and posterior human sclera may be enhanced by CXL with riboflavin/ultraviolet A irradiation. Equatorial scleral CXL may be a good choice for the treatment of progressive myopia. Because of its safety and efficacy, 20 minutes of riboflavin infiltration before CXL is recommended.

Based on dimensional analysis and finite element computations, an energy-based representative strain for conical indentation in elastoplastic materials has been proposed to establish an explicitly one-to-one relationship between the representative stress σr, the indentation loading curvature C, and the ratio of reversible work We to total work Wt performed by the indenter, i.e., σr/C = F0(We/Wt), where σr is the flow stress corresponding to the representative strain. The relationship provides a very simple method to evaluate the representative stress σr from the three directly measurable quantities We, Wt, and C. Numerical examples and further theoretical analysis reveal that a unique, stable solution can be obtained from the present method for a wide range of material properties, including both highly plastic materials (e.g., Ni for which E/σy = 1070) and highly elastic materials (e.g., materials for which E/σy = 25 and n = 0.5), using indenters with different tip apex angles. Based on the representative strains and stresses given by two indenters with different tip apex angles, e.g., (σr,80, ϵr,80) and (σr,65, ϵr,65), the plastic properties of materials, i.e., the yield strength σy and strain hardening exponent n can be further determined.

BackgroundGlaucoma is the primary cause of irreversible blindness worldwide associated with high intraocular pressure (IOP). Elevated intraocular pressure will affect the normal aqueous humor outflow, resulting in deformation of iris. However, the deformation ability of iris is closely related to its material properties. Meanwhile, the passive deformation of the iris aggravates the pupillary block and angle closure. The nature of the interaction mechanism of iris deformation and aqueous humor fluid flow has not been fully understood and has been somewhat a controversial issue. The purpose here was to study the effect of IOP, localization, and temperature on the flow of the aqueous humor and the deformation of iris interacted by aqueous humor fluid flow.MethodsBased on mechanisms of aqueous physiology and fluid dynamics, 3D model of anterior chamber (AC) was constructed with the human anatomical parameters as a reference. A 3D idealized standard geometry of anterior segment of human eye was performed. Enlarge the size of the idealization geometry model 5 times to create a simulation device by using 3D printing technology. In this paper, particle image velocimetry technology is applied to measure the characteristic of fluid outflow in different inlet velocity based on the device. Numerically calculations were made by using ANSYS 14.0 Finite Element Analysis. Compare of the velocity distributions to confirm the validity of the model. The fluid structure interaction (FSI) analysis was carried out in the valid geometry model to study the aqueous flow and iris change.ResultsIn this paper, the validity of the model is verified through computation and comparison. The results indicated that changes of gravity direction of model significantly affected the fluid dynamics parameters and the temperature distribution in anterior chamber. Increased pressure and the vertical position increase the velocity of the aqueous humor fluid flow, with the value increased of 0.015 and 0.035 mm/s. The results act on the iris showed that, gravity direction from horizontal to vertical decrease the equivalent stress in the normal IOP model, while almost invariably in the high IOP model. With the increased of the iris elasticity modulus, the equivalent strain and the total deformation of iris is decreased. The maximal value of equivalent strain of iris in high IOP model is higher than that of in normal IOP model. The maximum deformation of iris is lower in the high IOP model than in the normal IOP model.ConclusionThe valid model of idealization geometry of human eye could be helpful to study the relationship between localization, iris deformation and IOP. So far the FSI analysis was carried out in that idealization geometry model of anterior segment to study aqueous flow and iris change.